TRAMETINIB

To treat your condition effectually, continue taking TRAMETINIB for the period that your doctor has prescribed. Avoid taking TRAMETINIB if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, heart disease, blood or bleeding disorders, diabetes, eye problems, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below six years of age as the safety and efficacy are not established. TRAMETINIB may cause hypertension, thrombotic events, hemorrhagic events, ocular toxicity, cardiomyopathy, interstitial lung disease, colitis, gastrointestinal perforation, serious febrile reactions, severe skin reactions, venous thromboembolism and hyperglycemia in some patients. Hence, inform your doctor about your complete medication and medical history before taking TRAMETINIB.

Drug-Drug Interactions: TRAMETINIB may have interaction with CYP3A inhibitors (itraconazole, clarithromycin, fluconazole, erythromycin, diltiazem), CYP2C8 inhibitors (clopidogrel, warfarin, verapamil, ritonavir), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI disorders, and eye problems before starting the treatment.

• Eat food rich in antioxidants such as berries, spinach, etc.
• Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
• Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
• De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
• Avoid smoking and alcohol consumption.
• Maintain a healthy weight.

• Using contraceptive pills while using TRAMETINIB to prevent pregnancy is advised.
• Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.
• Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing, as it may be a sign of a heart problem.