Trypsin+bromelains+rutoside+papain
About
Trypsin+bromelains+rutoside+papain belongs to the class of medications called ‘analgesics’ used to treat pain associated with various conditions. It is used in the treatment of pain, swelling and inflammation associated with chronic (long-term) conditions such as osteoarthritis (joint pain, especially in the knees, hip, hands, neck, and lower back) and rheumatoid arthritis (joint pain, especially in the hands and feet). It can also relieve acute (short-term) pain such as toothache, ear pain, throat pain, muscle ache, and backache.
Trypsin+bromelains+rutoside+papain combines four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes and have antiseptic and anti-inflammatory properties. They reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. It can also promote healing. Rutoside is an antioxidant and anti-inflammatory agent. It prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage.
Trypsin+bromelains+rutoside+papain should be taken exactly as prescribed by your doctor. In some cases, Trypsin+bromelains+rutoside+papain may cause side effects such as nausea, vomiting, stomach pain, indigestion, heartburn, stomach upset, diarrhoea, headache, flushing (skin reddening), and skin rash. These side effects are usually mild and temporary. However, if any of these side effects persist or worsen, consult a doctor immediately.
Do not take Trypsin+bromelains+rutoside+papain if you are allergic to NSAIDs or any other contents of it. Trypsin+bromelains+rutoside+papain should not be used in patients with a history of stomach ulcers, active stomach ulcers or bleeding, or stomach problems due to NSAIDs, heart, liver, kidney disease, and poor blood circulation. Trypsin+bromelains+rutoside+papain should be used with caution in patients with ulcerative colitis (inflammation of the large intestine), other bowel disorders, porphyria ( an inherited blood disorder), bleeding disorders, asthma, other respiratory infections, hypertension (high blood pressure), history of blood clots, high cholesterol, diabetes, history of smoking, and systemic lupus erythematosus (a skin disease). Trypsin+bromelains+rutoside+papain should also be used with caution in pregnant and breastfeeding women. Trypsin+bromelains+rutoside+papain is not recommended for children below 12 years of age. Trypsin+bromelains+rutoside+papain may require dose adjustments when used in elderly people. Alcohol may increase the risk of liver damage and side effects, such as nausea, vomiting, and diarrhoea. Trypsin+bromelains+rutoside+papain may cause dizziness, so do not drive or operate heavy machinery if you are dizzy.
Uses of Trypsin+bromelains+rutoside+papain
Medicinal Benefits
Trypsin+bromelains+rutoside+papain is a combination of four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes and have antiseptic and anti-inflammatory properties. They reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. It can also promote healing. Rutoside is an antioxidant and anti-inflammatory agent. It prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. Trypsin+bromelains+rutoside+papain can be used to treat pain associated with osteoarthritis, rheumatoid arthritis, toothache, ear pain, throat pain, and muscle pain. It can provide quick relief from the pain and also promote faster healing of the affected tissue. It helps you to do your daily activities by decreasing the interference of pain and improving quality-of-life.
Directions for Use
Storage
Side Effects of Trypsin+bromelains+rutoside+papain
- Nausea
- Vomiting
- Stomach pain
- Indigestion
- Heartburn
- Stomach upset
- Diarrhoea
- Headache
- Flushing (skin reddening)
- Skin rash
In-Depth Precautions and Warning
Drug Warnings
Trypsin+bromelains+rutoside+papain should be used with caution in patients with heart diseases as it may increase heart rate. Trypsin+bromelains+rutoside+papain may cause liver damage, so regular monitoring of liver function is required if this medicine is taken for longer durations. If you are scheduled for surgery of the stomach or intestine, inform your doctor that you are taking the Trypsin+bromelains+rutoside+papain, as this medicine may delay wound healing. Do not overdose on medicine, as Trypsin+bromelains+rutoside+papain in higher doses may increase heart attack or stroke risk.
Drug Interactions
Drug-Drug Interactions: Trypsin+bromelains+rutoside+papain may interact with other painkillers (aspirin and ibuprofen), antibiotic (amoxicillin), blood thinners (warfarin), an antidepressant (lithium), anticancer agents (methotrexate), drugs that suppress the immune system (ciclosporin and tacrolimus), a medicine used to treat urinary tract infections (trimethoprim), abortion drug (mifepristone), a medication used to heart problems (digoxin), oral steroids, a medicine used to treat fits (phenytoin), antifungal agent (voriconazole), and medicines used to reduce cholesterol levels (colestipol and cholestyramine).
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: Trypsin+bromelains+rutoside+papain may interact with disease conditions including stomach ulcers, active stomach ulcers or bleeding, or stomach problems due to NSAIDs, heart, liver, kidney disease, and poor blood circulation. Trypsin+bromelains+rutoside+papain should be used with caution in patients with ulcerative colitis (inflammation of the large intestine), other bowel disorders, porphyria ( an inherited blood disorder), bleeding disorders, asthma, other respiratory infections, hypertension (high blood pressure), history of blood clots, high cholesterol, diabetes, and systemic lupus erythematosus (a skin disease).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may cause further liver damage and worsen side-effects of Trypsin+bromelains+rutoside+papain. So, limit the consumption of alcohol while using Trypsin+bromelains+rutoside+papain.
Pregnancy
unsafeTrypsin+bromelains+rutoside+papain may cause harmful effects to the unborn baby. So, it is used in pregnant women only if the doctor thinks the benefits outweigh the risks.
Breast Feeding
cautionTrypsin+bromelains+rutoside+papain should be used with caution in breastfeeding mothers as there is not enough research to establish the safe use of Trypsin+bromelains+rutoside+papain during breastfeeding.
Driving
cautionTrypsin+bromelains+rutoside+papain may cause headaches and dizziness. So, you should not drive or operate heavy machinery if you feel dizzy.
Liver
cautionTrypsin+bromelains+rutoside+papain may alter liver function. So, it should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.
Kidney
cautionTrypsin+bromelains+rutoside+papain should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.
Children
cautionTrypsin+bromelains+rutoside+papain is not recommended for children below 12 years of age.
Habit Forming
Diet & Lifestyle Advise
- Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on the treadmill, bike riding, and swimming. You can also strengthen your muscles by lifting light weights.
- In chronic arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize levels of chemicals called cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible, and only for a short duration of time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Special Advise
- Trypsin+bromelains+rutoside+papain may increase the heart rate. Inform your doctor about any such symptoms.
- Long-term use of Trypsin+bromelains+rutoside+papain may cause liver damage, and your doctor may advise liver function for regular monitoring of liver function.
Patients Concern
Disease/Condition Glossary
Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. It can be temporary (acute) or lifelong (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. While chronic pain lasts lifelong and can occur due to severe inflammation or tissue damage, such as osteoarthritis and rheumatoid arthritis. Extreme tissue pain and inflammation caused due to sprains, strains, trauma, or post-surgery may require prolonged healing time.
Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation, and tenderness.
Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities, and loss of joint function.
FAQs
Trypsin+bromelains+rutoside+papain combines four medicines: Trypsin, Bromelains, Rutoside, and Papain. Trypsin, Papain and Bromelain are enzymes that reduce pain, swelling, and inflammation by increasing the blood supply to the affected area. Rutoside is an antioxidant and prevents further swelling and inflammation by neutralizing the chemicals (free radicals) that cause cell damage. Together, Trypsin+bromelains+rutoside+papain can effectively treat pain associated with various conditions.
Trypsin+bromelains+rutoside+papain should not be used to treat period pain. You should discuss with your doctor before taking Trypsin+bromelains+rutoside+papain for any indication to avoid unwanted effects.
The common side-effects of Trypsin+bromelains+rutoside+papain are nausea, vomiting, stomach pain, indigestion, heartburn, stomach upset, diarrhoea, headache, flushing (skin reddening), and skin rash. These side effects are usually mild and temporary. However, if any of these side effects persist or get worse, consult a doctor immediately.
Trypsin+bromelains+rutoside+papain should not be taken with aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and aceclofenac. It may increase the risk of gastrointestinal (stomach and intestine) side effects.
Trypsin+bromelains+rutoside+papain is usually well-tolerated in most patients. However, it should be used with caution in patients with high blood pressure and high cholesterol as it increases the risk of a heart attack in higher doses. So, inform your doctor about your illnesses before taking this medicine.
Trypsin+bromelains+rutoside+papain may cause a change in the consistency and colour of the stools. Consult a doctor if the condition persists.