Acetylsalicylic Acid+atorvastatin+clopidogrel
About
Acetylsalicylic Acid+atorvastatin+clopidogrel belongs to a class of medication called 'cardiovascular drugs' used to prevent heart attack and stroke. It also lowers bad cholesterol and triglyceride (TG) levels. Heart attack refers to blocked blood flow to the heart due to blockage of arteries. The blockage is mostly a build-up of cholesterol, fat, and other substances that form a plaque in the arteries which feed the heart (coronary arteries). A stroke occurs due to blocked blood flow to the brain.
Acetylsalicylic Acid+atorvastatin+clopidogrel is a combination of two blood thinners (Acetylsalicylic acid, Clopidogrel) and one lipid-lowering agent (Atorvastatin). Acetylsalicylic acid and Clopidogrel work by inhibiting platelets (blood cells) from sticking together. Thereby, it prevents the formation of blood clots. Atorvastatin belongs to the class of lipid-lowering medicines called statins that works by inhibiting the HMG-CoA reductase enzyme in the body that is essential to make cholesterol, thereby decreasing the production of LDL (bad cholesterol) by the liver. Thus, it reduces the risk of stroke or heart attack by reducing the brain's excess cholesterol deposition and the heart's major blood vessels.
Take Acetylsalicylic Acid+atorvastatin+clopidogrel as prescribed by your doctor. You are advised to take Acetylsalicylic Acid+atorvastatin+clopidogrel for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience indigestion, nausea, headache, diarrhea, constipation, increased bleeding tendency, nose bleeding, blood in the urine, back pain, muscle pain, or joint pain. Most of these side effects of Acetylsalicylic Acid+atorvastatin+clopidogrel do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Acetylsalicylic Acid+atorvastatin+clopidogrel or any other medicines, please tell your doctor. Avoid using Acetylsalicylic Acid+atorvastatin+clopidogrel if you are pregnant or breastfeeding woman and consult a doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel. If you are about to undergo any surgery, inform your doctor that you are taking Acetylsalicylic Acid+atorvastatin+clopidogrel as it should be stopped a minimum of 1 week before surgery as Acetylsalicylic Acid+atorvastatin+clopidogrel may increase the risk of bleeding. Avoid taking Acetylsalicylic Acid+atorvastatin+clopidogrel if you have severe liver disease, including abnormal liver enzyme tests. You are recommended to maintain a time gap of 2 hours between taking Acetylsalicylic Acid+atorvastatin+clopidogrel and antacids containing magnesium or aluminum as taking these medicines simultaneously may reduce the absorption of Acetylsalicylic Acid+atorvastatin+clopidogrel.
Uses of Acetylsalicylic Acid+atorvastatin+clopidogrel
Medicinal Benefits
Acetylsalicylic Acid+atorvastatin+clopidogrel is a combination of three drugs: Acetylsalicylic acid, Clopidogrel, and Atorvastatin used to prevent heart attack and stroke. Acetylsalicylic acid and Clopidogrel work by reducing blood clot formation by preventing platelets (blood cells) from sticking together. Atorvastatin belongs to the class of lipid-lowering medicines called statins that inhibits the HMG-CoA reductase enzyme in the body that is essential to make cholesterol. Thereby, it decreases the production of LDL (bad cholesterol) by the liver. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.
Directions for Use
Storage
Side Effects of Acetylsalicylic Acid+atorvastatin+clopidogrel
- Indigestion
- Nausea
- Headache
- Diarrhea
- Constipation
- Increased bleeding tendency
- Nose bleed
- Blood in the urine
- Back pain
- Muscle pain
- Joint pain
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Acetylsalicylic Acid+atorvastatin+clopidogrel or any other medicines, please tell your doctor. If you have hypothyroidism (underactive thyroid gland), muscle problems, severe respiratory failure, asthma, high blood pressure, gout, stomach ulcer, bleeding disorders, liver, kidney, or heart problems, inform your doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel. Avoid using Acetylsalicylic Acid+atorvastatin+clopidogrel if you are a pregnant or breastfeeding woman and consult a doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel. If you are about to undergo any surgery, inform your doctor that you are carrying Acetylsalicylic Acid+atorvastatin+clopidogrel as it should be stopped a minimum of 2 weeks before surgery as Acetylsalicylic Acid+atorvastatin+clopidogrel may increase the risk of bleeding. Maintain a low-fat diet along with Acetylsalicylic Acid+atorvastatin+clopidogrel for effective results. Avoid taking Acetylsalicylic Acid+atorvastatin+clopidogrel if you have severe liver disease, including abnormal liver enzyme tests. You are recommended to maintain a time gap of 2 hours between taking Acetylsalicylic Acid+atorvastatin+clopidogrel and antacids containing magnesium or aluminum as taking these medicines simultaneously may reduce the absorption of Acetylsalicylic Acid+atorvastatin+clopidogrel. You are advised to be careful while using sharp objects, cutting nails, shaving, or engaging in contact sports such as wrestling or football as Acetylsalicylic Acid+atorvastatin+clopidogrel may increase bleeding risk.
Drug Interactions
Drug-Drug Interaction: Acetylsalicylic Acid+atorvastatin+clopidogrel may have interaction with other medicines used to lower bad cholesterol (gemfibrozil, fenofibrate, ezetimibe), immunosuppressants (ciclosporin, tacrolimus), blood thinners (warfarin, heparin, phenindione), antibiotics (clarithromycin, telithromycin, erythromycin, fusidic acid, rifampicin), antifungals (voriconazole, fluconazole), anticancer drug (methotrexate, paclitaxel), antiviral drugs (ritonavir, lopinavir, atazanavir, darunavir, indinavir), water tablets (furosemide), heart-related medicines (digoxin, amiodarone, verapamil), antimanic drug (lithium), anticonvulsants (valproate, phenytoin, carbamazepine), pain killer (ibuprofen), antidiabetic drug (glibenclamide), antacids (esomeprazole, omeprazole), antidepressants (sertraline, paroxetine, moclobemide), gout medicine (probenecid), medicines used to treat glaucoma (acetazolamide).
Drug-Food Interaction: Acetylsalicylic Acid+atorvastatin+clopidogrel may interact with grapefruit juice. Therefore, it is recommended to avoid the consumption of grapefruit juice with Acetylsalicylic Acid+atorvastatin+clopidogrel. This combination may increase the risk of liver damage and a serious condition known as rhabdomyolysis (muscle tissue breakdown). Also, avoid foods rich in high cholesterol or fats as it may reduce the effectiveness of Acetylsalicylic Acid+atorvastatin+clopidogrel. Avoid alcohol consumption with Acetylsalicylic Acid+atorvastatin+clopidogrel as it may increase the risk of liver problems or stomach bleeding. Acetylsalicylic Acid+atorvastatin+clopidogrel may also interact with St. John’s wort (herbal supplement for depression).
Drug-Disease Interaction: If you have hypothyroidism (underactive thyroid gland), muscle problems, severe respiratory failure, asthma, high blood pressure, gout, stomach ulcer, bleeding disorders, liver, kidney, or heart problems, inform your doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid consumption of alcohol with Acetylsalicylic Acid+atorvastatin+clopidogrel as it may increase the risk of stomach bleeding.
Pregnancy
unsafeAcetylsalicylic Acid+atorvastatin+clopidogrel is not recommended for pregnant women, especially in the last trimester as it may cause severe complications in mother or baby. Therefore, please consult a doctor if you are pregnant or planning for pregnancy.
Breast Feeding
unsafeAvoid breastfeeding while taking Acetylsalicylic Acid+atorvastatin+clopidogrel as it may be excreted in human milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.
Driving
safe if prescribedAcetylsalicylic Acid+atorvastatin+clopidogrel usually does not affect your ability to drive or operate machinery.
Liver
cautionTake Acetylsalicylic Acid+atorvastatin+clopidogrel with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Acetylsalicylic Acid+atorvastatin+clopidogrel is not recommended for patients with severe liver disease.
Kidney
cautionTake Acetylsalicylic Acid+atorvastatin+clopidogrel with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Acetylsalicylic Acid+atorvastatin+clopidogrel is not recommended for patients with severe kidney disease.
Children
unsafeAcetylsalicylic Acid+atorvastatin+clopidogrel is not recommended for children below 16 years of age as it may cause Reye’s syndrome (a life-threatening disease affecting brain and liver) in children. However, please consult a doctor before using Acetylsalicylic Acid+atorvastatin+clopidogrel in children.
Habit Forming
Diet & Lifestyle Advise
- Maintain a low-fat diet. Limit your intake of dairy products made with whole milk and red meat. Prefer skim milk and fat-free or low-fat dairy products.
- Eat a healthy diet that includes fruits, vegetables, fish, poultry, whole grains, nuts and cut down beverages, processed and sugary foods.
- Do regular exercises such as swimming, cycling, walking or dancing and focus on losing weight as obesity also raises bad cholesterol and lowers good cholesterol.
- Avoid smoking and alcohol intake.
Special Advise
- Regular lipid profile test is recommended to monitor your cholesterol levels, including LDL (bad cholesterol) and Triglycerides (TG).
- Avoid intake foods that contain saturated fatty acid.
- Prefer intake of food containing oils like polyunsaturated fatty acid (PUFA), monounsaturated fatty acid (MUFA), and omega 3 fatty acid.
Patients Concern
Disease/Condition Glossary
Heart attack: It refers to blocked blood flow to the heart due to blockage of arteries. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). A heart attack's symptoms include discomfort in the chest or upper areas of the body, shortness of breath, or lightheadedness.
Stroke: It occurs due to blocked blood flow to the brain. Symptoms of stroke include arm weakness and speech difficulty. Heart attack or stroke may occur due to high cholesterol, high blood pressure, diabetes, obesity, smoking, family history, or lack of physical activity.
FAQs
Acetylsalicylic Acid+atorvastatin+clopidogrel contains Acetylsalicylic acid, Clopidogrel and Atorvastatin. Acetylsalicylic acid and Clopidogrel works by reducing the formation of blood clots by preventing platelets (blood cells) from sticking together. Atorvastatin belongs to the class of lipid-lowering medicines called statins that inhibits the HMG-CoA reductase enzyme in the body that is essential to make cholesterol. Thereby, decreases the production of LDL (bad cholesterol) by the liver. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.
You are not recommended to take Acetylsalicylic Acid+atorvastatin+clopidogrel with warfarin as it may increase the risk of bleeding more easily. However, please consult your doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel with any other medicines.
You are recommended to avoid eating foods rich in fat or cholesterol. Also, avoid consumption of grapefruit juice with Acetylsalicylic Acid+atorvastatin+clopidogrel as it may increase the risk of liver damage and a serious condition known as rhabdomyolysis (muscle tissue break down).
You are not recommended to take Acetylsalicylic Acid+atorvastatin+clopidogrel with fusidic acid as co-administration of these two medicines may lead to a severe muscle problem known as rhabdomyolysis (the breakdown of muscle tissue). Therefore, inform your doctor if you have taken fusidic acid in the last 7 days before taking Acetylsalicylic Acid+atorvastatin+clopidogrel. You may be advised to stop taking Acetylsalicylic Acid+atorvastatin+clopidogrel if you need to take fusidic acid. However, please consult a doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel with any other medicines.
Acetylsalicylic Acid+atorvastatin+clopidogrel may increase the risk of developing diabetes especially if you have high levels of fats or sugars in the blood, high blood pressure or if you are overweight. Therefore, regular monitoring of blood sugar levels is recommended while taking Acetylsalicylic Acid+atorvastatin+clopidogrel and inform your doctor before taking Acetylsalicylic Acid+atorvastatin+clopidogrel if you have diabetes.
Acetylsalicylic Acid+atorvastatin+clopidogrel may cause muscle pain or back pain. It is not necessary for everyone taking Acetylsalicylic Acid+atorvastatin+clopidogrel to experience this side effect. However, if the pain persists or worsens, please consult your doctor.
