Acetylsalicylic Acid+clopidogrel+rosuvastatin
About
Acetylsalicylic Acid+clopidogrel+rosuvastatin belongs to a class of medicines known as 'cardiovascular agents' primarily used to prevent heart attack and stroke, especially in patients after bypass heart surgery. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).
Acetylsalicylic Acid+clopidogrel+rosuvastatin is composed of three medicines, namely: Aspirin, clopidogrel, rosuvastatin. Aspirin and clopidogrel together act as a blood-thinning agent (or anti-platelet agent) to prevent heart attack and stroke. They help to prevent blood clots by preventing the clubbing of platelets together. Rosuvastatin belongs to the class of drugs known as a cholesterol-lowering agent which works by blocking liver enzymes, causing the liver to make less cholesterol. Rosuvastatin lowers the bad cholesterol (low-density lipoprotein or LDL) levels and increases good cholesterol levels (high-density lipoprotein or HDL) in the bloodstream. Thus, Acetylsalicylic Acid+clopidogrel+rosuvastatin helps in the free flow of blood without forming any clog in the blood vessel's arteries, thereby preventing a heart attack, stroke and other peripheral vascular diseases.
Take Acetylsalicylic Acid+clopidogrel+rosuvastatin as prescribed by your doctor. You are advised to take Acetylsalicylic Acid+clopidogrel+rosuvastatin for as long as your doctor has prescribed it for you, depending on your medical condition. You may experience increased bleeding tendency, indigestion, abdominal pain, nosebleeds, weakness, muscle pain, headache, diarrhoea, gastrointestinal bleeding and nausea. Most of these side effects of Acetylsalicylic Acid+clopidogrel+rosuvastatin do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Try not to stop taking this medicine of your own. Stopping Acetylsalicylic Acid+clopidogrel+rosuvastatin may worsen your condition and increase the risk of a future heart attack. Let your doctor know if you are allergic to Acetylsalicylic Acid+clopidogrel+rosuvastatin or any ingredients of Acetylsalicylic Acid+clopidogrel+rosuvastatin. Acetylsalicylic Acid+clopidogrel+rosuvastatin should not be taken in the conditions like kidney/liver diseases, asthma, active bleeding issues (like peptic ulcer, brain haemorrhage), gastrointestinal disorders, diabetes and musculoskeletal disorder. If you are pregnant, planning to conceive or breastfeeding, it is essential to seek medical advice before starting Acetylsalicylic Acid+clopidogrel+rosuvastatin. Do not drive or operate machinery if you experience dizziness or drowsiness while using Acetylsalicylic Acid+clopidogrel+rosuvastatin. Acetylsalicylic Acid+clopidogrel+rosuvastatin is not recommended for children below the age of 16 years.
Uses of Acetylsalicylic Acid+clopidogrel+rosuvastatin
Medicinal Benefits
Acetylsalicylic Acid+clopidogrel+rosuvastatin is used to prevent myocardial infarction (heart attack), stroke or peripheral vascular disease. It also lowers abnormally elevated cholesterol or fat levels (dyslipidemia) in the body. Acetylsalicylic Acid+clopidogrel+rosuvastatin is composed of three medicines, namely: Aspirin, clopidogrel, rosuvastatin. Aspirin is a non-steroidal anti-inflammatory (NSAID) and anti-platelet drug that decreases blood clot formation by preventing the platelets from clubbing together. It is also used in heart-related revascularization procedures (provision of new blood supply to a body part), such as coronary artery bypass graft to improve the blood flow through the revascularized area. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke and peripheral arterial disease (heart problem due to narrow veins). Rosuvastatin is an antilipemic agent (cholesterol-lowering). It works by blocking liver enzymes, causing the liver to make less cholesterol. It also lowers the bad cholesterol (low-density lipoprotein or LDL) levels and increases good cholesterol levels (high-density lipoprotein or HDL) in the blood. Rosuvastatin reduces the risk of coronary events, such as heart attack, stroke and angina (chest pain).
Directions for Use
Storage
Side Effects of Acetylsalicylic Acid+clopidogrel+rosuvastatin
- Increased bleeding tendency
- Indigestion
- Abdominal pain
- Nosebleeds
- Weakness
- Muscle pain
- Headache
- Diarrhoea
- Gastrointestinal bleeding
- Nausea
In-Depth Precautions and Warning
Drug Warnings
Before taking Acetylsalicylic Acid+clopidogrel+rosuvastatin, let your doctor know if you have a history of liver and kidney diseases or allergic reactions to Acetylsalicylic Acid+clopidogrel+rosuvastatin. If you are at risk of internal bleeding (bleeding inside any tissues, organs, or joints of your body), a recent injury/surgery or a planned surgery (including dental) in the next few days, blood clotting disorder and active bleeding issues (like peptic ulcer, brain hemorrhage), please inform your doctor before starting Acetylsalicylic Acid+clopidogrel+rosuvastatin. It is important to tell your doctor if you have any kidney/liver diseases, asthma, gastrointestinal disorders, diabetes, musculoskeletal disorder or mental illnesses like memory loss, forgetfulness, amnesia, memory impairment and confusion before using Acetylsalicylic Acid+clopidogrel+rosuvastatin. Acetylsalicylic Acid+clopidogrel+rosuvastatin may have harmful effects on the baby when a pregnant mother uses it. Also, salicylates in Aspirin of Acetylsalicylic Acid+clopidogrel+rosuvastatin can pass into the breast milk and cause rashes and bleeding issues in infants. If you are pregnant, planning to conceive or breastfeeding, it is essential to seek medical advice before starting Acetylsalicylic Acid+clopidogrel+rosuvastatin. Avoid using other over the counter medications, herbal or vitamin supplements without medical advice.
Drug Interactions
Drug-Drug Interactions: Acetylsalicylic Acid+clopidogrel+rosuvastatin may interact with blood thinners (rivaroxaban, apixaban, warfarin, heparin, phenindione, ticlopidine, coumarin), gout medicines (probenecid), anti-cancer or anti-arthritis drug (methotrexate), anti-platelet drugs (clopidogrel, dipyridamole), antidepressants (lithium, sertraline, paroxetine), immune-related drugs (cyclosporine, tacrolimus), anti-epilepsy drug (valproate, phenytoin), pain killers (meloxicam, celecoxib, naproxen, ibuprofen), anti-diabetic drugs (insulin glargine), blood pressure medicines (lisinopril), cholesterol-lowering drugs (gemfibrozil, fenofibrate), antacids and oral contraceptives.
Drug-Food Interactions: Limit alcohol intake since it may cause a rise in blood pressure leading to heart diseases. Avoid fatty foods to help control your cholesterol and triglyceride levels. Caffeine may have minor interactions with Aspirin in Acetylsalicylic Acid+clopidogrel+rosuvastatin.
Drug-Disease Interactions: Acetylsalicylic Acid+clopidogrel+rosuvastatin is contraindicated in the liver, kidney diseases, active bleeding disorders, asthma, gastrointestinal bleeding disorders, diabetes, musculoskeletal disorder (myopathy) and viral infections.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeIt is unsafe to consume alcohol since it may worsen the side effects like dizziness and increases blood pressure.
Pregnancy
unsafeAcetylsalicylic Acid+clopidogrel+rosuvastatin is a pregnancy category X drug and is unsafe to use during pregnancy since it has harmful effects on the fetus. If the patient becomes pregnant while using Acetylsalicylic Acid+clopidogrel+rosuvastatin, please discontinue immediately and consult your doctor if you are planning to conceive or already pregnant before starting Acetylsalicylic Acid+clopidogrel+rosuvastatin.
Breast Feeding
unsafeAcetylsalicylic Acid+clopidogrel+rosuvastatin is not recommended for use if you are lactating, since salicylates in aspirin pass through the breast milk and can cause rashes, platelet abnormalities and bleeding in nursing infants. Please consult your doctor before starting Acetylsalicylic Acid+clopidogrel+rosuvastatin.
Driving
cautionDo not drive or operate machinery if you experience dizziness or drowsiness while using Acetylsalicylic Acid+clopidogrel+rosuvastatin. Acetylsalicylic Acid+clopidogrel+rosuvastatin can also sometimes cause blurry vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.
Liver
cautionLet your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Acetylsalicylic Acid+clopidogrel+rosuvastatin. However, it is not recommended in patients with severe liver diseases.
Kidney
cautionLet your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Acetylsalicylic Acid+clopidogrel+rosuvastatin. However, it is not recommended in patients with severe kidney diseases.
Children
cautionAcetylsalicylic Acid+clopidogrel+rosuvastatin is not recommended for children below the age of 16 years. The safety and efficacy of Acetylsalicylic Acid+clopidogrel+rosuvastatin have not been established in children due to limited testing of this drug on children by competent authorities across the world.
Habit Forming
Diet & Lifestyle Advise
- Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Acetylsalicylic Acid+clopidogrel+rosuvastatin.
- A low-cholesterol diet and regular exercise regime are found to complement treatment with Acetylsalicylic Acid+clopidogrel+rosuvastatin effectively.
- Keep your cholesterol and triglyceride levels under control.
- Eat at regular intervals and maintain a healthy diet that includes fresh fruits, vegetables.
- The high-fat meal should be avoided as it may further increase the risk of a heart attack instead of eating heart-healthy foods.
- Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.
- Keep a check on your weight and exercise regularly to keep your heart healthy.
- Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases.
Special Advise
- Explain your doctor about your complete medical history like haemophilia, stomach ulcers, low blood cell count (platelets, red or white blood cells), liver disease.
- Your doctor may advice regular examination of lungs a aspirin in Acetylsalicylic Acid+clopidogrel+rosuvastatin may worsen the symptoms of ashtma.
Patients Concern
Disease/Condition Glossary
Heart attack: It occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). During a heart attack (myocardial infarction), the blood supply which nourishes the heart with oxygen is cut off. Heart attack signs include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.
Stroke: It occurs when a blockage of blood supply to a part of the brain prevents brain tissues from getting enough oxygen and nutrients.
Angina: It is a type of heart-related chest pain which occurs due to reduced or blocked blood flow to the heart. This is a common sign and symptom of coronary artery disease in which arteries get clogged due to the deposition of an excessive amount of cholesterol in the heart's arteries.
FAQs
Yes, diarrhea may occur as a side effect of Acetylsalicylic Acid+clopidogrel+rosuvastatin. Drinking plenty of fluids and eating light non-spicy meals would be helpful. If you are suffering from severe diarrhea or if you notice blood in stool or urine, please inform your doctor.
Acetylsalicylic Acid+clopidogrel+rosuvastatin consists of Aspirin and Clopidogrel. These are blood-thinning agents and can increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails or using sharp objects. Also, please consult your doctor beforehand if you undergo any surgery.
Please consult your doctor if Acetylsalicylic Acid+clopidogrel+rosuvastatin needs to be discontinued before undergoing a dental procedure or any surgery. The doctor might ask you to stop taking Acetylsalicylic Acid+clopidogrel+rosuvastatin a few days before surgery since it can cause an increased risk of bleeding during surgery.
Acetylsalicylic Acid+clopidogrel+rosuvastatin can cause dizziness as one of its side effects. Please consult your doctor if you feel dizzy for a longer time. Avoid driving or operating machinery during episodes of dizziness.
Acetylsalicylic Acid+clopidogrel+rosuvastatin is composed of three medicines, namely: Aspirin, clopidogrel, rosuvastatin. Aspirin is a non-steroidal anti-inflammatory drug (NSAID) with anti-platelet action. Aspirin and clopidogrel act as a blood-thinning or anti-platelet agent to prevent heart attack and stroke. They decrease the formation of blood clots by preventing the platelets from clubbing together. Rosuvastatin belongs to the class of drugs known as Antilipemic agent (cholesterol-lowering). It works by blocking liver enzymes, causing the liver to make less cholesterol. Rosuvastatin lowers the bad cholesterol (low-density lipoprotein or LDL) levels and increases good cholesterol levels (high-density lipoprotein or HDL) in the blood. Acetylsalicylic Acid+clopidogrel+rosuvastatin helps in the free flow of blood, thereby preventing a heart attack, stroke, and other peripheral vascular diseases.
Acetylsalicylic Acid+clopidogrel+rosuvastatin contains aspirin, clopidogrel which are anti platelets, they may increase the chance of bleeding. Consult your doctor before using Acetylsalicylic Acid+clopidogrel+rosuvastatin and explain your through medical history.
