Dexrabeprazole+domperidone
About
Dexrabeprazole+domperidone belongs to a group of medicines called gastrointestinal agents used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, dyspepsia (indigestion), and peptic ulcers. The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to acidity-related problems.
Dexrabeprazole+domperidone is a combination of two drugs, namely: Dexrabeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Dexrabeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscle. Together, Dexrabeprazole+domperidone helps in treating acidity related problems.
You are advised to take Dexrabeprazole+domperidone for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Inform your doctor if you have a history of gastrointestinal bleeding or intestinal obstruction. Consult your doctor before taking Dexrabeprazole+domperidone if you are pregnant or breastfeeding. Dexrabeprazole+domperidone may cause dizziness, so drive only if you are alert. Dexrabeprazole+domperidone is not recommended for children as safety has not been established. Avoid consuming alcohol with Dexrabeprazole+domperidone as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Dexrabeprazole+domperidone
Medicinal Benefits
Dexrabeprazole+domperidone is a combination of two drugs, namely: Dexrabeprazole and Domperidone. Dexrabeprazole+domperidone is used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, dyspepsia (indigestion), epigastric pain, and peptic ulcers. Dexrabeprazole is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, Dexrabeprazole+domperidone helps in treating acidity-related problems.
Directions for Use
Storage
Side Effects of Dexrabeprazole+domperidone
- Dry mouth
- Stomach pain
- Diarrhoea
- Headache
- Flatulence
In-Depth Precautions and Warning
Drug Warnings
Do not take Dexrabeprazole+domperidone if you are allergic to any of its components. Inform your doctor if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems, HIV infection, blockage in intestines, pituitary gland tumour, low levels of potassium or magnesium in the blood. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Dexrabeprazole+domperidone. Consult your doctor if you are pregnant or breastfeeding. Dexrabeprazole+domperidone may cause dizziness, so drive only if you are alert.
Drug Interactions
Drug-Drug Interactions: Dexrabeprazole+domperidone may interact with a blood thinner (warfarin), anti-fungal (ketoconazole, fluconazole, voriconazole), antibiotic (ampicillin, erythromycin, clarithromycin), digitalis glycoside (digoxin), anti-depressants (citalopram, escitalopram).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in the stomach or intestine, low level of potassium, low/high levels of magnesium, or heart problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Dexrabeprazole+domperidone. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Pregnancy
cautionConsult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor if you are breastfeeding; your doctor will decide whether Dexrabeprazole+domperidone can be taken by breastfeeding mothers or not.
Driving
cautionDexrabeprazole+domperidone may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed. Consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionDexrabeprazole+domperidone should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Special Advise
- Inform your doctor if you are due to have Chromogranin A blood test.
- On long-term treatment, Dexrabeprazole+domperidone may cause low magnesium levels, vitamin B12 levels and increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition.
Patients Concern
Disease/Condition Glossary
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, peptic ulcers and Zollinger-Ellison syndrome.
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of the protective stomach lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Zollinger-Ellison syndrome: It is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Dexrabeprazole+domperidone contains Dexrabeprazole and Domperidone. Dexrabeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Dexrabeprazole+domperidone helps in treating acidity.
Diarrhoea might be a side-effect of Dexrabeprazole+domperidone. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or if you find blood in stools.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Dexrabeprazole+domperidone. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevents drying of the mouth.
Do not take Dexrabeprazole+domperidone for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Dexrabeprazole+domperidone for 14days.
On long-term treatment, Dexrabeprazole+domperidone might increase the risk of bone fracture in the spine, wrist or hip. Inform your doctor if you have osteoporosis or if you are taking corticosteroids, as they can increase the risk of bone fractures.
