Estradiol+estradiol+dydrogesterone
About
Estradiol+estradiol+dydrogesterone is a hormone replacement therapy (HRT) used to treat postmenopausal symptoms and prevent osteoporosis (weak and brittle bones) caused by menopause in women. Postmenopause is a condition in which women have not had a period for 12 months or longer. The oestrogen levels decrease in postmenopausal women resulting in symptoms such as hot flushes (hot neck, face and chest). Osteoporosis is a bone disease that weakens and thins bones by decreasing bone density which is common in post-menopausal women.
Estradiol+estradiol+dydrogesterone contains two female hormones, namely, Estradiol and Dydrogesterone. Estradiol works by replacing the falling levels of oestrogen in the body and thus helps to reduce menopause symptoms. Dydrogesterone works by reducing the overgrowth of the womb lining. Together, Estradiol+estradiol+dydrogesterone helps treat postmenopausal symptoms and osteoporosis.
Take Estradiol+estradiol+dydrogesterone as prescribed by your doctor. You are advised to take Estradiol+estradiol+dydrogesterone for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, headache, breast pain or tenderness and back pain. Most of these side effects of Estradiol+estradiol+dydrogesterone do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Estradiol+estradiol+dydrogesterone or any other medicines, please tell your doctor. Avoid taking Estradiol+estradiol+dydrogesterone if you are pregnant or breastfeeding and consult a doctor. Estradiol+estradiol+dydrogesterone is not recommended for children. You are advised to avoid alcohol consumption with Estradiol+estradiol+dydrogesterone as it may increase the risk of breast cancer. If you have premature menopause, inform your doctor before taking Estradiol+estradiol+dydrogesterone so that the risks and benefits may be compared.
Uses of Estradiol+estradiol+dydrogesterone
Medicinal Benefits
Estradiol+estradiol+dydrogesterone contains Estradiol and Dydrogesterone used to treat postmenopausal symptoms and prevent osteoporosis (weak and brittle bones) caused by menopause in women. Estradiol restores the falling levels of oestrogen in the body and thus helps to reduce menopause symptoms. Dydrogesterone decreases the overgrowth of the womb lining. Also, Estradiol+estradiol+dydrogesterone prevents osteoporosis in postmenopausal women and prevents bone loss and fractures.
Directions for Use
Storage
Side Effects of Estradiol+estradiol+dydrogesterone
- Stomach pain
- Headache
- Breast pain or tenderness
- Back pain
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Estradiol+estradiol+dydrogesterone or any other medicines, please tell your doctor. Avoid taking Estradiol+estradiol+dydrogesterone if you are pregnant or breastfeeding and consult a doctor. Estradiol+estradiol+dydrogesterone is not recommended for children. If you have premature menopause, inform your doctor before taking Estradiol+estradiol+dydrogesterone so that the risks and benefits may be compared. Avoid taking Estradiol+estradiol+dydrogesterone if you have recently had a stroke, heart attack or angina (chest pain). If you have very high levels of fat (triglycerides) in blood, inform your doctor before taking Estradiol+estradiol+dydrogesterone. You are recommended to avoid alcohol consumption with Estradiol+estradiol+dydrogesterone as it may increase the risk of breast cancer. If you experience sudden chest pain, difficulty breathing, or painful swelling and redness of legs, stop taking Estradiol+estradiol+dydrogesterone and consult a doctor immediately as these might be signs of a blood clot.
Drug Interactions
Drug-Drug Interactions: Estradiol+estradiol+dydrogesterone may interact with anticonvulsants (phenytoin, carbamazepine, phenobarbital), antitubercular drugs (rifabutin, rifampicin), anti-HIV drugs (efavirenz, nelfinavir, ritonavir, nevirapine), painkiller (fentanyl), bronchodilator (theophylline) and immunosuppressants (cyclosporine, tacrolimus).
Drug-Food Interactions: Estradiol+estradiol+dydrogesterone may interact with St. John’s wort (herbal medicine to treat depression).
Drug-Disease Interactions: If you have high blood pressure, gallstones, diabetes, migraine, epilepsy (fits), asthma, fluid retention due to kidney or heart problems, unexplained vaginal bleeding, breast cancer, liver disease, systemic lupus erythematosus (an autoimmune disease), oestrogen-sensitive cancer, porphyria, fibroids in the womb, endometrial hyperplasia (excessive thickening of the womb lining), blood clotting disorder or blood clot in the vein, inform your doctor before taking Estradiol+estradiol+dydrogesterone.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol with Estradiol+estradiol+dydrogesterone as it may increase the risk of breast cancer and delay healing.
Pregnancy
unsafeEstradiol+estradiol+dydrogesterone is only recommended for postmenopausal women. Therefore, avoid taking Estradiol+estradiol+dydrogesterone and consult a doctor if you are pregnant.
Breast Feeding
unsafeAvoid taking Estradiol+estradiol+dydrogesterone if you are breastfeeding and consult a doctor.
Driving
safe if prescribedEstradiol+estradiol+dydrogesterone usually does not affect your ability to drive or operate machinery.
Liver
cautionTake Estradiol+estradiol+dydrogesterone with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Estradiol+estradiol+dydrogesterone with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeEstradiol+estradiol+dydrogesterone is not recommended for children as it is intended for use in postmenopausal women.
Habit Forming
Diet & Lifestyle Advise
- Include dairy products like milk, yoghurt, cheese, or milk-based custard in your diet.
- Eat daily a serving of broccoli, cabbage, bok choy (Chinese white cabbage), spinach, and other green leafy vegetables.
- Snack on calcium-rich nuts like Brazil nuts or almonds.
- Sprinkle sesame seeds over your food, vegetables, and salads. Sesame seeds are high in calcium.
- Avoid or reduce the intake of caffeine, soft drinks, and alcohol that inhibit calcium absorption.
- Replace the meat with tofu or tempeh for extra calcium in your food.
Special Advise
- Regular breast screening is recommended while taking Estradiol+estradiol+dydrogesterone.
- Check your breasts regularly for any changes in the nipple, dimpling of the skin or any lumps.
Patients Concern
Disease/Condition Glossary
Postmenopause: It is a condition in which women have not had a period for 12 months or longer. The oestrogen levels decrease in postmenopausal women resulting in symptoms such as hot flushes (hot neck, face and chest).
Osteoporosis: It is a bone disease that weakens and thins bones by decreasing bone density. As the density of bones decreases, they weaken and are more likely to break. Post-menopausal women are more likely to develop osteoporosis than men because, at menopause, a woman’s ovaries stop production of oestrogen (a female hormone) that is essential to keep bones healthy. Following menopause, bone loss occurs, making bones weak and more likely to break. Signs and symptoms include back pain caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more easily than expected.
FAQs
Estradiol+estradiol+dydrogesterone contains two female hormones namely, Estradiol and Dydrogesterone. Estradiol works by replacing the falling levels of oestrogen in the body and thus helps to reduce menopause symptoms. Dydrogesterone works by reducing the overgrowth of the womb lining. Also, Estradiol+estradiol+dydrogesterone is used to prevent postmenopausal osteoporosis.
Estradiol+estradiol+dydrogesterone may cause irregular bleeding or spotting (drops of blood) during the first 3 to 6 months of taking Estradiol+estradiol+dydrogesterone. However, if the bleeding or spotting continues for more than 6 months or after discontinuing Estradiol+estradiol+dydrogesterone, please consult a doctor immediately.
You may be advised to stop taking Estradiol+estradiol+dydrogesterone about 4 to 6 weeks before surgery to decrease the risk of a blood clot. Therefore, inform your doctor that you are taking Estradiol+estradiol+dydrogesterone before undergoing any surgery.
Estradiol+estradiol+dydrogesterone is not a contraceptive. Estradiol+estradiol+dydrogesterone is a hormone replacement therapy. Therefore, if you are less than 50 years old or if it is less than 12 months since your last period, you are advised to use additional contraceptive measures to avoid pregnancy. However, discuss with a doctor if you have any concerns regarding this.
Estradiol+estradiol+dydrogesterone may interfere with certain test results. Therefore, if you are about to undergo blood test or any laboratory tests, inform your doctor or lab technician that you are taking Estradiol+estradiol+dydrogesterone.
