Glibenclamide+metformin+rosiglitazone
About Glibenclamide+metformin+rosiglitazone
Glibenclamide+metformin+rosiglitazone belongs to a class of medicines called antidiabetic drugs used in the treatment of type 2 diabetes, especially in patients whose blood sugar levels are not controlled by diet and exercise alone. Type 2 diabetes is a chronic (long-lasting) condition that affects the way our body processes glucose. People with type 2 diabetes either do not produce enough insulin or the insulin produced is unable to perform its function in the body (insulin resistance).
Glibenclamide+metformin+rosiglitazone is a combination of three antidiabetic drugs, namely: Glibenclamide, Metformin, and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Rosiglitazone works by increasing the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, Glibenclamide+metformin+rosiglitazone helps to control blood sugar levels.
Take Glibenclamide+metformin+rosiglitazone as prescribed by your doctor. You are advised to take Glibenclamide+metformin+rosiglitazone for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience stomach pain, nausea, diarrhea, vomiting, headache, or low blood sugar. Most of these side effects of Glibenclamide+metformin+rosiglitazone do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Glibenclamide+metformin+rosiglitazone or any other medicines, please tell your doctor. Glibenclamide+metformin+rosiglitazone is not recommended for children below 18 years of age. Avoid breastfeeding while taking Glibenclamide+metformin+rosiglitazone as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Glibenclamide+metformin+rosiglitazone as it may harm an unborn baby. Glibenclamide+metformin+rosiglitazone should be used with caution in elderly patients. Avoid alcohol consumption with Glibenclamide+metformin+rosiglitazone as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Glibenclamide+metformin+rosiglitazone.
Uses of Glibenclamide+metformin+rosiglitazone
Medicinal Benefits
Glibenclamide+metformin+rosiglitazone contains three antidiabetic drugs (Glibenclamide, Metformin, and Rosiglitazone) used in the treatment of type 2 diabetes. Glibenclamide stimulates cells in the pancreas that produce insulin which helps to remove sugar from the blood. Metformin reduces sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone increases the sensitivity of liver, muscle, and fat cells to insulin and enables cells to remove glucose from blood more effectively. Also, it decreases the amount of glucose produced by the liver and preserves the functioning of beta cells in the pancreas that produce insulin. Thereby, Glibenclamide+metformin+rosiglitazone helps to control blood sugar levels.
Directions for Use
Storage
Side Effects of Glibenclamide+metformin+rosiglitazone
- Stomach pain
- Nausea
- Diarrhoea
- Vomiting
- Headache
- Low blood sugar
Drug Warnings
If you are allergic to Glibenclamide+metformin+rosiglitazone or any other medicines, please tell your doctor. Glibenclamide+metformin+rosiglitazone is not recommended for children. Avoid breastfeeding while taking Glibenclamide+metformin+rosiglitazone as it may be excreted in human milk. If you are pregnant or planning for pregnancy, please inform your doctor before taking Glibenclamide+metformin+rosiglitazone as it may harm the unborn baby. Glibenclamide+metformin+rosiglitazone should be used with caution in elderly patients. Avoid alcohol consumption with Glibenclamide+metformin+rosiglitazone as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body). Drive only if you are alert after taking Glibenclamide+metformin+rosiglitazone. Take short, frequent meals and avoid prolonged fasting while taking Glibenclamide+metformin+rosiglitazone. Beware of symptoms of hypoglycemia (low blood sugar) which include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience any of these symptoms, immediately consume 5-6 candies or 3 glucose biscuits, or 3 teaspoons of honey/sugar, and also consult your doctor. Make sure to carry these with you at all times, especially during long travels.
Drug Interactions
Drug-Drug Interaction: Glibenclamide+metformin+rosiglitazone may have interaction with drugs used to treat high blood pressure in the lungs (bosentan), other antidiabetic drugs (insulin, sitagliptin), water pill (furosemide), antithyroid drugs (levothyroxine), anticonvulsant (pregabalin).
Drug-Food Interaction: Glibenclamide+metformin+rosiglitazone may interact with alcohol. Therefore, avoid the consumption of alcohol with Glibenclamide+metformin+rosiglitazone as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
Drug-Disease Interaction: If you have type 1 diabetes, lactic acidosis, diabetic ketoacidosis (accumulation of ketone bodies in the blood), or eye problems caused by diabetes, liver, kidney, or heart problems, inform your doctor before taking Glibenclamide+metformin+rosiglitazone.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid consumption of alcohol with Glibenclamide+metformin+rosiglitazone as it may increase the risk of lactic acidosis (accumulation of lactic acid in the body).
Pregnancy
unsafeGlibenclamide+metformin+rosiglitazone is not recommended for pregnant women as it may harm an unborn baby. Please consult a doctor if you are pregnant or planning for pregnancy.
Breast Feeding
unsafeAvoid breastfeeding while taking Glibenclamide+metformin+rosiglitazone as it may be excreted in breastmilk and cause adverse effects in the baby. Therefore, please consult a doctor before using Glibenclamide+metformin+rosiglitazone if you are breastfeeding.
Driving
cautionGlibenclamide+metformin+rosiglitazone may decrease alertness in some people. Therefore, drive only if you are alert after taking Glibenclamide+metformin+rosiglitazone.
Liver
cautionTake Glibenclamide+metformin+rosiglitazone with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Glibenclamide+metformin+rosiglitazone with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeGlibenclamide+metformin+rosiglitazone is not recommended for children below 18 years of age as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Do regular exercise such as cycling, walking, jogging, dancing, or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
- Maintain healthy body weight as obesity is also related to the onset of diabetes.
- Maintain a low-fat and low-sugar diet. Replace carbohydrates-containing foods with whole grains, fruits, and vegetables as carbohydrates turn to sugars leading to high blood sugar.
- Avoid consumption of alcohol and quit smoking.
Special Advise
- Regular blood tests are recommended while taking Glibenclamide+metformin+rosiglitazone to monitor blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include frequent urination at night, increased thirst, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.
FAQs
Glibenclamide+metformin+rosiglitazone contains Glibenclamide, Metformin and Rosiglitazone. Glibenclamide works by stimulating beta cells in the pancreas that produce insulin. Thus, insulin helps to remove sugar from the blood. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Also, it increases the sensitivity of muscle cells to insulin which enables these cells to remove sugar more effectively from the blood. Rosiglitazone works by increasing the sensitivity of liver, muscle and fat cells to insulin and enables cells to remove glucose from blood more effectively. Thereby, Glibenclamide+metformin+rosiglitazone helps to control blood sugar levels.
Glibenclamide+metformin+rosiglitazone may increase the risk of low blood sugar levels, especially with alcohol intake, when you exercise more than usual, delay or miss snacks or meal. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.
You are not recommended to take Glibenclamide+metformin+rosiglitazone with levothyroxine as it may reduce the hypoglycemic (lowering blood sugar levels) effect of metformin. However, please consult a doctor before using Glibenclamide+metformin+rosiglitazone with other medicines.
In type 1 diabetes, the body doesn’t produce insulin as the islet cells (insulin-producing cells) in the pancreas are destroyed completed. In type 2 diabetes, though islet cells are working, the body doesn’t respond to insulin as the body becomes resistant to insulin.
You are not recommended to stop taking Glibenclamide+metformin+rosiglitazone on your own as discontinuing Glibenclamide+metformin+rosiglitazone suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Glibenclamide+metformin+rosiglitazone, please consult your doctor so that alternative medicine may be prescribed.
