Glycopyrrolate+neostigmine
About
Glycopyrrolate+neostigmine belongs to a group of medicines called 'anticholinesterase agents/acetylcholinesterase inhibitors', primarily used to reverse the effects of muscle relaxant and anesthesia medicines used during surgery. Certain medicines like propofol, etomidate, ketamine which is an anesthetic medicine cause anesthesia (sedative action) during surgery. Several muscles relaxant medicines are also used during surgery like vecuronium, rocuronium relaxes the muscles during surgery.
Glycopyrrolate+neostigmine contains two medicines namely: Glycopyrrolate and Neostigmine. Neostigmine increases levels of a substance known as acetylcholine by stopping an enzyme required for the breakdown of acetylcholine involved in transmission between nerve impulses and muscle movements. It is used at the end of surgery to reverse the effects of several medicines used during surgery like anesthetics and muscle relaxants. Glycopyrrolate is an anticholinergic It works by blocking the activity of a chemical messenger (acetylcholine) in the brain. It is added to avoid the unwanted effects of Neostigmine like stomach acid, excess saliva production and decreased heart rate.
You are advised to take Glycopyrrolate+neostigmine for as long as your doctor has prescribed it for you depending on your medical condition. Some people may experience constipation, dry mouth, nausea, vomiting, visual disturbance, dizziness, diarrhea, too much saliva, dryness of skin, increased pressure of the eye, stomach cramps, the uncontrolled need of passing urine. Most of these side effects of Glycopyrrolate+neostigmine do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Do not use Glycopyrrolate+neostigmine if you are allergic to Glycopyrrolate+neostigmine or any of its contents. Glycopyrrolate+neostigmine should not be taken if you have difficulty in passing urine and blockage in the intestine. Glycopyrrolate+neostigmine should not be taken in the conditions like asthma, kidney disease and heart disease. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Glycopyrrolate+neostigmine. It is not recommended to drive after taking Glycopyrrolate+neostigmine as it may cause your eyesight to become week. Glycopyrrolate+neostigmine can be given to children if prescribed by the doctor, the dose depends on the child’s age and weight.
Uses of Glycopyrrolate+neostigmine
Medicinal Benefits
Glycopyrrolate+neostigmine contains two medicines namely: Glycopyrrolate and Neostigmine. It is primarily used to reverse the effects of muscle relaxant and anesthesia medicines at the end of surgery. Neostigmine increases levels of a substance known as acetylcholine by stopping an enzyme required for the breakdown of acetylcholine involved in transmission between nerve impulses and muscle movements. It is used at the end of surgery to reverse the effects of several medicines used during surgery like anesthetics and muscle relaxants. Glycopyrrolate is an anticholinergic It works by blocking the activity of a chemical messenger (acetylcholine) in the brain. It is added to avoid the unwanted effects of Neostigmine like stomach acid, excess saliva production and decreased heart rate.
Directions for Use
Side Effects of Glycopyrrolate+neostigmine
- Constipation
- Dry mouth
- Nausea
- Vomiting
- Visual disturbance
- Dizziness
- Diarrhea
- Too much saliva
- Dryness of skin
- Increased pressure of the eye
- Stomach cramps
- Uncontrolled need of passing urine
In-Depth Precautions and Warning
Drug Warnings
Let your doctor know if you use any other medicines or supplements before using Glycopyrrolate+neostigmine. Do not use Glycopyrrolate+neostigmine if you are allergic to Glycopyrrolate+neostigmine or any of its contents. Glycopyrrolate+neostigmine should not be taken if you have difficulty in passing urine and blockage in the intestine. Glycopyrrolate+neostigmine should not be taken in the conditions like asthma, breathing difficulties, stomach ulcers, high blood pressure, high temperature (fever), kidney disease, and heart disease. Before taking Glycopyrrolate+neostigmine inform your doctor if you have muscle weakness (myasthenia gravis), fit disorder, parkinson’s disease, enlarged prostate gland, abdominal pain and vomiting. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Glycopyrrolate+neostigmine. It is not recommended to drive after taking Glycopyrrolate+neostigmine as it may cause your eyesight to become week. Glycopyrrolate+neostigmine can be given to children if prescribed by the doctor; the dose depends on the child’s age and weight.
Drug Interactions
Drug-Drug Interaction: Glycopyrrolate+neostigmine may interact with antidepressants (lithium, amitriptyline, imipramine), medicines used for mental illness (clozapine), pain killers (nefopam), antiviral (amantadine), muscle relaxants (suxamethonium), antibiotics (gentamicin, streptomycin, cholistimethate sodium), medicines for heart disease (procainamide, propafenone, quinidine), antimalarial (chloroquine), a medicine used in migraine (propranolol).
Drug-Food Interaction: Do not consume alcohol while taking Glycopyrrolate+neostigmine as it could lead to increased dizziness and weak eyesight.
Drug-Disease Interaction: Glycopyrrolate+neostigmine may have interactions with asthma, muscle weakness, stomach ulcers, high blood pressure, high temperature (fever), kidney disease, and heart disease
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consuming alcohol while taking Glycopyrrolate+neostigmine as it may cause increased dizziness.
Pregnancy
cautionGlycopyrrolate+neostigmine contains neostigmine which is a pregnancy category C drug. It may be unsafe to use during pregnancy since animal studies of Glycopyrrolate+neostigmine showed harmful effects on the fetus. Please consult your doctor before taking Glycopyrrolate+neostigmine if you are pregnant or planning to conceive.
Breast Feeding
cautionIt is not known if Glycopyrrolate+neostigmine is excreted into the breast milk. Please consult your doctor before taking Glycopyrrolate+neostigmine if you are a breastfeeding mother.
Driving
unsafeGlycopyrrolate+neostigmine can make you feel dizzy, eyesight becomes a week and affect your ability to drive. It is advised not to drive or operate machinery while using Glycopyrrolate+neostigmine if you are not mentally alert and focused.
Liver
cautionIf u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking Glycopyrrolate+neostigmine. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Kidney
cautionIf u have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking Glycopyrrolate+neostigmine. Your doctor will weigh the benefits and any potential risks before prescribing it to you.
Children
safe if prescribedGlycopyrrolate+neostigmine can be given to children with caution if prescribed by the doctor, the dose depends on the child’s age and weight.
Habit Forming
Diet & Lifestyle Advise
- Maintain proper weight by following a healthy diet.
- Avoid smoking and alcohol consumption.
- Try to avoid stress by practising meditation or yoga.
- Include fruits and vegetables in your diet as they contain anti-oxidants.
- Limit foods with high cholesterol and saturated fats.
- Cut down on sugar, salt and processed foods.
- Drink plenty of water.
Special Advise
Do not use Glycopyrrolate+neostigmine on your own, it is given only by a doctor.
Patients Concern
Disease/Condition Glossary
Anesthesia is the use of medicines to avoid pain during surgery. These medicines are known as anesthetics. They may be given by injection, inhalation, topical lotion, spray, eye drops or skin patch. They cause you to have a loss of awareness or feeling. Specific medicines like propofol, etomidate, ketamine which is an anesthetic medicine cause anesthesia (sedative action) during surgery. Several muscles relaxant medicines are also used during surgery like vecuronium, rocuronium relaxes the muscles during surgery.
FAQs
Glycopyrrolate+neostigmine contains two medicines namely: Glycopyrrolate and Neostigmine. Neostigmine increases levels of a substance known as acetylcholine by stopping an enzyme required for the breakdown of acetylcholine involved in transmission between nerve impulses and muscle movements. It is used at the end of surgery to reverse the effects of several medicines used during surgery like anesthetics and muscle relaxants. Glycopyrrolate is an anticholinergic It works by blocking the activity of a chemical messenger (acetylcholine) in the brain. It is added to avoid the unwanted effects of neostigmine like stomach acid, excess saliva production and decreased heart rate.
Glycopyrrolate+neostigmine should be used with caution in the medical history of asthma, breathing problems, stomach ulcers, high temperature, high blood pressure, heart attack, heart disease, overactive thyroid (hypothyroidism). Please let your doctor know if you have any other medical problems before starting Glycopyrrolate+neostigmine.
Do not stop taking Glycopyrrolate+neostigmine on your own. To treat your condition effectually please continue taking Glycopyrrolate+neostigmine for the prescribed period. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Glycopyrrolate+neostigmine.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
Keep Glycopyrrolate+neostigmine in a cool, dry place away from direct sunlight. Dispose of unused medicine and keep it out of sight and reach from children and pets.
