Lamivudine+zidovudine+nevirapine
About
Lamivudine+zidovudine+nevirapine is a combination of three drugs: lamivudine, zidovudine, and nevirapine. Lamivudine+zidovudine+nevirapine works by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body and also increasing the CD4 cell (white blood cells that protect against infection) count in your blood. Lamivudine+zidovudine+nevirapine is generally prescribed for the treatment of HIV infection.
lamivudine and zidovudine is nucleosidase reverse transcriptase inhibitor, both medicines together decrease the amount of virus in your body by inhibiting HIV reverse transcription via viral DNA chain termination, whereas Niverapine is a non-nucleosidase reverse transcriptase inhibitor, works by lowering the amount of HIV in the blood. Lamivudine+zidovudine+nevirapine will not cure HIV infection or AIDS, however, it helps keep HIV from reproducing and appears to slow down the destruction of the immune system.
Take Lamivudine+zidovudine+nevirapine by mouth with a glass full of water. Take it on an empty stomach, preferably at bedtime, to reduce side effects. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Common side effects of Lamivudine+zidovudine+nevirapine are Nausea, Vomiting, Diarrhea, Headache, Tiredness, Insomnia (difficulty in sleeping), Rash, Muscle damage, Anemia (low number of red blood cells), and Decreased white blood cell count (neutrophils).
Lamivudine+zidovudine+nevirapine should not be prescribed for people who are allergic to any one of the components in the name. $ name carries a boxed warning for the risk of life-threatening (including fatal) hepatotoxicity, skin reactions, hematologic toxicity, myopathy, lactic acidosis and severe hepatomegaly with steatosis, and exacerbations of hepatitis B. Lamivudine+zidovudine+nevirapine may cause dizziness or sleepiness, so don't drive or do anything requiring concentration until you know how it affects you. It can cause birth defects, use effective contraception while taking Lamivudine+zidovudine+nevirapine, and 12 weeks after stopping it. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Do not stop taking Lamivudine+zidovudine+nevirapine without your doctor’s advice.
Uses of Lamivudine+zidovudine+nevirapine
Medicinal Benefits
Lamivudine+zidovudine+nevirapine is a combination of three medicines that slows down or stops the progression of HIV infections. Lamivudine+zidovudine+nevirapine work by preventing HIV (virus) from multiplying, thereby reducing the amount of virus in your body. They also increase the CD4 cell (white blood cells that protect against infection) count in your blood. Lamivudine+zidovudine+nevirapine is also used in preventing pregnancy complications.
Directions for Use
Storage
Side Effects of Lamivudine+zidovudine+nevirapine
- Nausea
- Vomiting
- Diarrhea
- Headache
- Tiredness
- Insomnia (difficulty in sleeping)
- Rash
- Muscle damage
- Anemia (low number of red blood cells)
- Decreased white blood cell count (neutrophils)
- Chills and fever
- Indigestion
- Difficulty with bowel movements
In-Depth Precautions and Warning
Drug Warnings
Lamivudine+zidovudine+nevirapine should not be prescribed for people who are allergic to any one of the components in the name. Lamivudine+zidovudine+nevirapine carries a boxed warning for the risk of life-threatening (including fatal) hepatotoxicity, skin reactions, hematologic toxicity, myopathy, lactic acidosis and severe hepatomegaly with steatosis, and exacerbations of hepatitis B. Lamivudine+zidovudine+nevirapine may cause dizziness or sleepiness, so don't drive or do anything requiring concentration until you know how it affects you. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. Do not stop taking Lamivudine+zidovudine+nevirapine without your doctor’s advice.
Drug Interactions
Drug-Drug Interaction: Care should be exercised when Lamivudine+zidovudine+nevirapine is administered in combination with antibiotics(clarithromycin, chloramphenicol, Doxorubicin), anti-viral (acyclovir, atazanavir, efavirenz),anti-fungal(fluconazole, ketoconazole).
Drug-Food Interaction: avoid taking alcohol and st .johnwarts with Lamivudine+zidovudine+nevirapine.
Drug-Disease Interaction: People affected with liver disease, kidney disease, blood disorders, and Bone disorders should not take Lamivudine+zidovudine+nevirapine.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeLamivudine+zidovudine+nevirapine with alcohol causes liver damage. so Inform Your doctor while prescribing the Lamivudine+zidovudine+nevirapine.
Pregnancy
cautionLamivudine+zidovudine+nevirapine can be used in pregnancy by the advice of your doctor because studies do not show any defects in the unborn baby as Lamivudine+zidovudine+nevirapine passes through the placenta.
Breast Feeding
cautionLamivudine+zidovudine+nevirapine can be used in breastfeeding mothers by the advice of your doctor because studies do not show any defects in baby as Lamivudine+zidovudine+nevirapine passes through breast milk.
Driving
unsafeLamivudine+zidovudine+nevirapine may cause dizziness or sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
Liver
cautionIf you take Lamivudine+zidovudine+nevirapine, Your doctor may monitor your liver functions regularly. Inform your doctor if you develop abdominal pain symptoms, loss of appetite, yellowing of the eyes or skin. If needed dose adjustments can be made by your doctor.
Kidney
cautionIf you take Lamivudine+zidovudine+nevirapine, Your doctor may monitor your kidney functions regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite darkened urine. If needed dose adjustments can be done by your doctor.
Children
unsafeLamivudine+zidovudine+nevirapine cannot be used in children below 12 years. If their age is >35 can be prescribed and dose adjustments can be done by your doctor.
Habit Forming
Diet & Lifestyle Advise
- Getting moderate exercise. Being physically active three to six times a week can help improve your mood and outlook and improve your overall quality of life.
- quit smoking and avoid alcohol
- Take healthy diet for someone living with HIV is one that is rich in whole grains, low-fat dairy products, protein, and lots of fresh fruits and vegetables.
- If you have HIV, you can get infections more easily. so always wash your hands well and often, and practice good food safety to avoid foodborne illness.
Special Advise
- Take it on an empty stomach, preferably at bedtime, to reduce side effects.
- Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
- $ name can cause congenital disabilities. Use effective contraception while taking Lamivudine + Zidovudine + Nevirapine and 12 weeks after stopping it.
- Lamivudine+zidovudine+nevirapine may cause the weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
- Your doctor may monitor your kidney and liver functions regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine, or yellowing of the eyes or skin.
Patients Concern
Disease/Condition Glossary
HIV (human immunodeficiency virus) is a virus that attacks the body’s immune system. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). There is currently no effective cure. Once people get HIV, they have it for life. But with proper medical care, HIV can be controlled. People with HIV who get effective treatment can live long, healthy lives and protect their partners. Some people have flu-like symptoms within 2 to 4 weeks after infection (called acute HIV infection). These symptoms may last for a few days or several weeks. Possible symptoms include Fever, Chills, Rash, Night sweats, Muscle aches, Sore throat, Fatigue, Swollen lymph nodes, and Mouth ulcers.
FAQs
Skipping doses of Lamivudine+zidovudine+nevirapine increases the risk of treatment failure. Make sure that you take all your doses at the correct time.
Yes,Lamivudine+zidovudine+nevirapine cause the weakening of bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.
Patients taking nevirapine one of the component of Lamivudine+zidovudine+nevirapine may develop severe liver disease or skin reactions that can cause death. The risk of these reactions is greatest during the first 18 weeks of treatment, but these reactions also can occur later.
