Mesalamine
About
Mesalamine belongs to a class of drugs called 'anti-inflammatory drugs used to treat ulcerative colitis and Crohn’s disease. Ulcerative colitis is a type of chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus.
Mesalamine contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby, it reduces inflammation (swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.
Take Mesalamine as prescribed. You are advised to use Mesalamine for as long as your doctor has recommended it for you based on your medical condition. In some cases, you may experience diarrhoea, stomach pain, headache, nausea, vomiting or flatulence (gas). Most of these side effects of Mesalamine do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Inform your doctor if you are allergic to any components present in Mesalamine. Mesalamine should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before taking Mesalamine. Mesalamine tablet is not recommended for children below two years, and granules are not recommended for children below six years. However, Mesalamine should be given to children only if advised by a doctor. Avoid taking Mesalamine if you have severe kidney failure. If you have stomach pain, cramps, severe headache, fever or rash, stop taking Mesalamine immediately and consult a doctor.
Uses of Mesalamine
Medicinal Benefits
Mesalamine contains Mesalamine, an anti-inflammatory drug used to treat ulcerative colitis and Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helping reduce inflammation (redness and swelling) in the intestines and providing relief from symptoms such as stomach pain or bleeding. Also, Mesalamine may prevent further episodes of ulcerative colitis.
Directions for Use
Storage
Side Effects of Mesalamine
- Diarrhoea
- Stomach pain
- Headache
- Nausea
- Vomiting
- Flatulence (gas)
In-Depth Precautions and Warning
Drug Warnings
Inform your doctor if you're allergic to any ingredient in the Mesalamine. Mesalamine should be used with caution in the elderly. If you are pregnant or breastfeeding, inform your doctor before taking Mesalamine. Avoid taking Mesalamine if you have severe kidney failure. Severe skin reactions such as toxic epidermal necrolysis (skin peeling and blistering) or Stevens-Johnson syndrome (a painful rash that spreads and blisters) can occur in some patients taking Mesalamine. Therefore, if you notice any skin reactions while taking Mesalamine, please consult a doctor immediately. If you have stomach pain, cramps, severe headache, fever or rash, stop taking Mesalamine immediately and consult a doctor. Avoid taking Mesalamine if you have had blood abnormalities or kidney problems while taking other medicines such as Sulphasalazine.
Drug Interactions
Drug-Drug Interactions: Mesalamine may have interaction with a laxative (lactulose), painkillers (aspirin, ibuprofen), immunosuppressants (azathioprine), chemotherapy drugs (thioguanine, mercaptopurine).
Drug-Food Interactions: No interactions found.
Drug-Disease Interactions: If you have a stomach ulcer, a blockage in the stomach, asthma, or any medical condition that can cause bleeding, liver, kidney, or blood problems, inform your doctor before taking Mesalamine.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is unknown whether it is safe to consume alcohol with Mesalamine. However, as a precautionary measure, it is advisable not to take or limit alcohol.
Pregnancy
cautionMesalamine should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing this medicine.
Breast Feeding
cautionMesalamine should not be used in nursing mothers unless necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing this medicine.
Driving
not applicableMesalamine usually does not affect your ability to drive or operate machinery.
Liver
consult your doctorLimited information is available about using Mesalamine in patients with liver disease. Inform your doctor before taking Mesalamine if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.
Kidney
consult your doctorInform your doctor before taking Mesalamine if you have a history of kidney diseases/conditions. Mesalamine should be used with extreme caution in patients with mild to moderate kidney impairment. It is recommended not to take Mesalamine if you have severe kidney impairment.
Children
cautionMesalamine tablet is not recommended for children below two years, and granules are not recommended for children below six years. However, Mesalamine should be given to children only if recommended by a doctor.
Habit Forming
Diet & Lifestyle Advise
- Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley, and berries, to help heal faster.
- Include olive oil and omega-3 fatty acids.
- Eat more fibre-rich foods such as fruits and vegetables.
- Limit dairy intake as your body may develop difficulty digesting certain dairy products when affected with Crohn’s disease, leading to stomach cramps, diarrhoea, or stomach upset.
- Drink plenty of water to prevent dehydration.
Special Advise
- Blood and urine tests are recommended before and during the treatment with Mesalamine to monitor the functioning of the kidney, liver, and blood.
Patients Concern
Disease/Condition Glossary
Ulcerative colitis: Ulcerative colitis is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite, or nausea. The factors involved in causing ulcerative colitis include immune disorders, environmental factors like viruses, bacteria, or antigens, which may trigger the immune system, and genes inherited from the parent.
Crohn’s disease: Crohn’s disease is a type of chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract, from mouth to anus. But mostly occurs in the small intestine and large intestine. The symptoms include blood in stools, stomach cramps, tiredness, diarrhoea, fever, weight loss, or loss of appetite.
FAQs
Mesalamine contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
Yes, Mesalamine may cause diarrhoea as a common side effect. However, if the condition persists and worsens with fever, watery stools, or consistent stomach pain, please consult a doctor. Also, drink plenty of water while taking Mesalamine to prevent dehydration.
You are not recommended to take Mesalamine with Ibuprofen as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Mesalamine with other medicines.
Yes, Mesalamine may cause kidney stones in some patients. It is not necessary for everyone taking Mesalamine to experience this side effect. However, if you notice blood in urine or pain in the sides of the stomach, please consult a doctor immediately. Drink adequate water while taking Mesalamine to prevent kidney stones.
Mesalamine should be used with caution in patients with stomach ulcers as it may increase the risk of worsening the condition. Therefore, please inform your doctor if you have a stomach ulcer before taking Mesalamine.
Some people may develop lactose intolerance (inability to digest lactose) when affected by Crohn’s disease. Therefore, it is recommended to avoid dairy products if you have Crohn’s disease as it may lead to adverse effects such as diarrhoea, stomach cramps, or stomach upset.
