Metoprolol+s Amlodipine
About
Metoprolol+s Amlodipine belongs to a class of medication called anti-hypertensive agents primarily used in the treatment of hypertension (high blood pressure). Also, Metoprolol+s Amlodipine is used to treat chest pain, irregular heart rhythm. Hypertension is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease.
Metoprolol+s Amlodipine is a combination of two drugs, namely: Metoprolol (beta-blocker) and S-Amlodipine (calcium channel blocker). Metoprolol works by blocking beta receptors in the heart and makes the heart to beat slowly and with less force. Thereby, it decreases the pressure at which blood is pumped out of the heart and throughout the body. S-Amlodipine works by acting on muscle cells in the artery walls and relaxes muscle cells. Thereby, relaxes and widens arteries (blood vessels) and improves the blood flow and oxygen supply to the heart. Thus, together they lower high blood pressure.
Take Metoprolol+s Amlodipine as prescribed by your doctor. You are advised to take Metoprolol+s Amlodipine for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience tiredness, dizziness, slow heart rate, nausea, headache, orthostatic hypotension (low blood pressure when standing up from sitting or lying position), stomach pain or fluid retention. Most of these side effects of Metoprolol+s Amlodipine do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.
If you are allergic to Metoprolol+s Amlodipine or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before taking Metoprolol+s Amlodipine. Avoid drinking alcohol with Metoprolol+s Amlodipine as it may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness or headache. Drive only if you are alert as Metoprolol+s Amlodipine may cause dizziness or tiredness. Avoid grapefruit or grapefruit juice with Metoprolol+s Amlodipine as it may increase the risk of severe low blood pressure.
Uses of Metoprolol+s Amlodipine
Medicinal Benefits
Metoprolol+s Amlodipine contains Metoprolol and S-Amlodipine primarily used to treat high blood pressure. Metoprolol belongs to beta-blockers that block beta receptors in the heart and make the heartbeat slowly and with less force. Thereby, it decreases the pressure at which blood is pumped out of the heart and throughout the body. S-Amlodipine is a calcium channel blocker that acts on muscle cells in the artery walls and relaxes muscle cells. Thereby, relaxes and widens arteries (blood vessels) and improves the blood flow and oxygen supply to the heart. Thus, together they lower high blood pressure.
Directions for Use
Storage
Side Effects of Metoprolol+s Amlodipine
- Tiredness
- Dizziness
- Slow heart rate
- Nausea
- Headache
- Orthostatic hypotension (low blood pressure when standing up from sitting or lying position)
- Stomach pain
- Fluid retention
In-Depth Precautions and Warning
Drug Warnings
If you are known to be allergic to Metoprolol+s Amlodipine or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before taking Metoprolol+s Amlodipine. Complete the full course of medication and do not stop taking Metoprolol+s Amlodipine suddenly as it may cause recurring symptoms or worsen the condition. Avoid grapefruit or grapefruit juice with Metoprolol+s Amlodipine as it may increase the risk of severe low blood pressure. Avoid taking Metoprolol+s Amlodipine if you have blood circulation or heart problems, Prinzmetal’s angina (painful feeling in the chest in periods of rest), asthma, chronic obstructive pulmonary disease (COPD), breathing problems, phaeochromocytoma (tumour in the adrenal gland), low blood pressure, diabetes or metabolic acidosis (increased acidity of the blood). Avoid drinking alcohol with Metoprolol+s Amlodipine as it may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness or headache. Drive only if you are alert as Metoprolol+s Amlodipine may cause dizziness or tiredness. If you are about to under any surgery or receive anaesthetics, please inform your doctor or dentist that you are taking Metoprolol+s Amlodipine as it may cause a very slow heartbeat.
Drug Interactions
Drug-Drug Interaction: Metoprolol+s Amlodipine may have interaction with pain killers (aspirin), antidepressants (duloxetine, nefazodone), water tablets (furosemide), anticonvulsants (phenytoin, phenobarbital, carbamazepine), medicines used to lower high blood pressure (verapamil, diltiazem, nifedipine, disopyramide), drugs to treat irregular heartbeat (quinidine, amiodarone, propafenone), antidiabetic drug (insulin glargine), thyroid medicines (levothyroxine), benzodiazepine (alprazolam), blood thinner (apixaban), lower high cholesterol-lowering medicines (atorvastatin).
Drug-Food Interaction: Metoprolol+s Amlodipine may interact with grapefruit or grapefruit juice as it may increase the risk of severe low blood pressure. Metoprolol+s Amlodipine may interact with St. John’s wort (herbal supplement used to treat depression). Also, avoid alcohol consumption as it may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness or headache.
Drug-Disease Interaction: Avoid taking Metoprolol+s Amlodipine if you have blood circulation or heart problems, Prinzmetal’s angina (painful feeling in the chest in periods of rest), asthma, chronic obstructive pulmonary disease (COPD), breathing problems, phaeochromocytoma (tumour in the adrenal gland), low blood pressure, diabetes or metabolic acidosis (increased acidity of the blood). If you have slow heart rate, psoriasis (severe skin rashes), myasthenia gravis (muscle weakness), dry eyes, diabetes, kidney, liver or heart problems, inform your doctor before taking Metoprolol+s Amlodipine.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption with Metoprolol+s Amlodipine as it may increase the risk of low blood pressure and cause adverse effects such as dizziness, fainting, light-headedness or headache.
Pregnancy
cautionMetoprolol+s Amlodipine is a category C pregnancy drug. Metoprolol+s Amlodipine is given to pregnant women only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are pregnant.
Breast Feeding
cautionMetoprolol+s Amlodipine may be excreted in human milk in small amounts. Therefore, Metoprolol+s Amlodipine is given to breastfeeding mothers if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.
Driving
cautionMetoprolol+s Amlodipine may cause dizziness or tiredness in some people. Therefore, avoid driving if you feel dizzy or tired after taking Metoprolol+s Amlodipine.
Liver
cautionMetoprolol+s Amlodipine should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionMetoprolol+s Amlodipine should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeIt is not recommended for children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
- Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day.
- Chronic stress may also cause high blood pressure. Therefore, avoid stress triggers and make time for yourself to relax and do activities that you enjoy.
- Maintain a diet that is rich in vegetables, fruits, whole grains and low-fat dairy products.
- Try to include heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil which may help in lowering high blood pressure.
- Quit smoking and avoid the consumption of alcohol.
Special Advise
- Regular monitoring of blood pressure is recommended while taking Metoprolol+s Amlodipine.
- Metoprolol+s Amlodipine may rarely cause changes in blood tests and liver function tests.
- Low salt diet and regular exercise are recommended along with Metoprolol+s Amlodipine for effective results.
- Your doctor may advice regular blood test for monitoring of electrolytes.
Patients Concern
Disease/Condition Glossary
Hypertension: Blood pressure is the measurement of the force that the heart uses to pump blood to all parts of the body. Hypertension is a chronic condition in which blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and, diastolic pressure is 90 mm of Hg. Normal blood pressure lies in between 90/60 mm of Hg and 120/80 mm of Hg. If the blood pressure is 140/90 mmHg or greater, it is considered as high blood pressure.
FAQs
Metoprolol+s Amlodipine contains Metoprolol and S-Amlodipine. Metoprolol works by blocking beta receptors in the heart and making the heartbeat slowly and with less force. Thereby, it decreases the pressure at which blood is pumped out of the heart and throughout the body. S-Amlodipine works by acting on muscle cells in the artery walls and relaxing muscle cells and widening arteries (blood vessels), thereby improving the blood flow and oxygen supply to the heart. Thus, together they lower high blood pressure.
You are not recommended to take furosemide with Metoprolol+s Amlodipine as co-administration of these two medicines may increase the risk of low blood pressure. However, if you experience dizziness, reduced heart rate, headache or fainting, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted to use safely.
Metoprolol+s Amlodipine should be used with caution in diabetic patients as it may increase the risk of severe low blood sugar levels. Therefore, if you have diabetes, inform your doctor before taking Metoprolol+s Amlodipine. Also, regular monitoring of blood sugar levels is recommended while taking Metoprolol+s Amlodipine.
Metoprolol+s Amlodipine may cause dizziness when standing up from sitting or lying position suddenly. Therefore, to avoid such effects, it is advised to stand up slowly from sitting or lying position.
You are not recommended to take Metoprolol+s Amlodipine if you asthma or chronic obstructive pulmonary disease (COPD) as it may worsen the condition. However, please consult a doctor before taking Metoprolol+s Amlodipine.
Metoprolol+s Amlodipine may cause high potassium levels in the blood and cause adverse effects on overdose. Therefore, take Metoprolol+s Amlodipine only in doses as prescribed by your doctor.
