Nimesulide+paracetamol+tizanidine
About
Nimesulide+paracetamol+tizanidine is a combination medicine used to relieve pain due to muscle spasms such as arthritis, muscle pain, tooth pain, bone and joint pain, headache, and period pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
Nimesulide+paracetamol+tizanidine contains Nimesulide (analgesic), Paracetamol (mild analgesic and fever reducer), and Tizanidine (muscle relaxant). Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, Nimesulide+paracetamol+tizanidine helps in reducing pain due to muscle spasms.
You are advised to take Nimesulide+paracetamol+tizanidine for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as nausea, vomiting, dizziness, dry mouth, and diarrhoea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Nimesulide+paracetamol+tizanidine may cause dizziness, so drive with caution. Nimesulide+paracetamol+tizanidine should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with Nimesulide+paracetamol+tizanidine as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Uses of Nimesulide+paracetamol+tizanidine
Medicinal Benefits
Nimesulide+paracetamol+tizanidine is a combination of three drugs, namely: Tizanidine, Nimesulide, and Paracetamol. Nimesulide+paracetamol+tizanidine is a combination medicine used to relieve pain and inflammation associated with osteoarthritis, muscle pain, tooth pain, bone and joint pain, headache, and period pain. Tizanidine is a muscle relaxant that works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Nimesulide and Paracetamol are analgesics that work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Together, Nimesulide+paracetamol+tizanidine helps in relieving pain due to muscle spasms.
Directions for Use
Storage
Side Effects of Nimesulide+paracetamol+tizanidine
- Nausea
- Vomiting
- Dizziness
- Diarrhoea
- Dry mouth
- Loss of appetite
- Indigestion
In-Depth Precautions and Warning
Drug Warnings
Do not take Nimesulide+paracetamol+tizanidine if you are allergic to any of its contents, if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine, or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Nimesulide+paracetamol+tizanidine may cause dizziness, so drive only if you are alert. Nimesulide+paracetamol+tizanidine is not recommended for children as safety and effectiveness have not been established. Stop taking Nimesulide+paracetamol+tizanidine and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other analgesic for pain relief along with Nimesulide+paracetamol+tizanidine unless prescribed.
Drug Interactions
Drug-Drug Interactions: Nimesulide+paracetamol+tizanidine may interact with pain killers (hydrocodone), anti-depressants (escitalopram, duloxetine, sertraline), anti-psychotic (lithium), anti-rheumatoid (methotrexate), immunosuppressants (cyclosporin), hypnotic (zolpidem), anti-convulsant (pregabalin), antihistamine (diphenhydramine, cetirizine).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have/had stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anaemia, heart, kidney, or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Nimesulide+paracetamol+tizanidine as it may cause increased drowsiness. It can also increase the risk of stomach bleeding.
Pregnancy
cautionPlease consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. Nimesulide+paracetamol+tizanidine should not be taken during the last three months of pregnancy.
Breast Feeding
cautionConsult your doctor before taking Nimesulide+paracetamol+tizanidine, your doctor will decide whether Nimesulide+paracetamol+tizanidine can be taken by breastfeeding mothers or not.
Driving
cautionNimesulide+paracetamol+tizanidine may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionNimesulide+paracetamol+tizanidine should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
- Massages can also be helpful.
- Avoid freezing and hot temperatures.
- Avoid wearing tight-fitting clothes, instead, wear loose garments.
- Rest well, and get plenty of sleep.
- To avoid developing pressure sores, change your position every two hours.
- Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
- Stay hydrated, drink plenty of water.
Special Advise
- Do not use Nimesulide+paracetamol+tizanidine when you need muscle tone for safe balance and body movement during various activities. In some cases, it may be dangerous for you to have reduced muscle tone.
Patients Concern
Disease/Condition Glossary
Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute or chronic, can be localized or wide-spread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure, or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, and soreness
Arthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation, and tenderness.
FAQs
Nimesulide+paracetamol+tizanidine contains Nimesulide, Paracetamol, and Tizanidine. Nimesulide and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation at the injured or damaged site. Tizanidine works on the centres of the spinal cord and brain, which helps relieve muscle stiffness, thereby improving muscle movements. Together, Nimesulide+paracetamol+tizanidine helps in reducing pain due to muscle spasms.
Nimesulide+paracetamol+tizanidine is used to reduce and relieve pain and inflammation associated with osteoarthritis. Arthritis is tenderness and swelling in the joints.
Diarrhoea might be a side-effect of Nimesulide+paracetamol+tizanidine. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.
Nimesulide+paracetamol+tizanidine should not be taken for longer durations unless prescribed by the doctor. Use the minimum effective dose for the shortest duration.
Dry mouth could be a side-effect of Nimesulide+paracetamol+tizanidine. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevents drying of the mouth.
Taking Nimesulide+paracetamol+tizanidine can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Nimesulide+paracetamol+tizanidine if you have gastrointestinal bleeding or other bleeding problems like haemophilia before using Nimesulide+paracetamol+tizanidine.
