Olmesartan Medoxomil+amlodipine+hydrochlorothiazide
About
Olmesartan Medoxomil+amlodipine+hydrochlorothiazide belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. High blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it increases the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.
Olmesartan Medoxomil+amlodipine+hydrochlorothiazide is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmesartan Medoxomil+amlodipine+hydrochlorothiazide lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.
Depending upon your medical condition, you are advised to take Olmesartan Medoxomil+amlodipine+hydrochlorothiazide for as long as your doctor has prescribed it for you. The most common side effects of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide are nausea, upset stomach, dehydration, headache, diarrhoea, electrolyte imbalance, headache, feeling exhausted, swollen ankles, dizziness, and decreased blood pressure in some cases. Most of these side effects of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Do not use potassium supplements or salt substitutes unless your doctor tells you. In rare cases, Olmesartan Medoxomil+amlodipine+hydrochlorothiazide can cause a condition that results in a skeletal muscle problem, leading to further kidney failure. If you notice unexplained muscle pain, dark-coloured urine, tenderness, or weakness, especially if you also have a fever or unexplained tiredness, immediately contact the doctor. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase heart disease and stroke risk. Inform your doctor if you are suffering from kidney, liver, heart disease, or diabetes. If you are pregnant or breastfeeding, do not take Olmesartan Medoxomil+amlodipine+hydrochlorothiazide as it is a category D pregnancy drug and may harm the baby. Do not use the Olmesartan Medoxomil+amlodipine+hydrochlorothiazide if you cannot urinate, are dehydrated, have low blood pressure (hypotension), or have had cardiogenic shock (sudden stopping blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing table salt (sodium chloride) in your food often helps lower blood pressure.
Uses of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide
Medicinal Benefits
Olmesartan Medoxomil+amlodipine+hydrochlorothiazide belongs to a group of medications called 'anti-hypertensives' primarily used for lowering high blood pressure (hypertension) by removing extra fluid (electrolytes) from the body. Olmesartan Medoxomil+amlodipine+hydrochlorothiazide is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil is a prodrug and breaks down into active form, i.e., olmesartan once absorbed in the GIT (Gastrointestinal tract). An angiotensin receptor blocker (ARB) blocks the hormone angiotensin, thereby relaxing and widening the narrowed blood vessels. Amlodipine is a calcium channel blocker; it reduces the heart's workload and makes it more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmesartan Medoxomil+amlodipine+hydrochlorothiazide lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.
Directions for Use
Storage
Side Effects of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide
- Nausea
- Upset stomach
- Dehydration
- Headache
- Dry mouth
- Muscle cramps/weakness
- Fast/slow/irregular heartbeat
- Diarrhoea
- Electrolyte imbalance
- Headache
- Feeling exhausted
- Swollen ankles
- Dizziness
- Decreased blood pressure
In-Depth Precautions and Warning
Drug Warnings
Do not use Olmesartan Medoxomil+amlodipine+hydrochlorothiazide if you are pregnant, planning for pregnancy, or unable to urinate (anuria). If you have diabetes and taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide with other blood pressure-lowering pills like 'aliskiren,' immediately stop taking both together and consult a doctor. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Olmesartan Medoxomil+amlodipine+hydrochlorothiazide may pass into breast milk, so before starting Olmesartan Medoxomil+amlodipine+hydrochlorothiazide, either you need to stop nursing or you should not take Olmesartan Medoxomil+amlodipine+hydrochlorothiazide while breastfeeding. Please inform your doctor before surgery if you are taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia. Avoid potassium salt or its substitute intake while using Olmesartan Medoxomil+amlodipine+hydrochlorothiazide to avoid any electrolyte imbalance. Olmesartan Medoxomil+amlodipine+hydrochlorothiazide can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you take Olmesartan Medoxomil+amlodipine+hydrochlorothiazide and breastfeeding.
Drug Interactions
Drug-drug interactions: Olmesartan Medoxomil+amlodipine+hydrochlorothiazide may interact with an antidepressant (lithium), heart rhythm controlling medicines (digoxin), blood thinner (aspirin), antidiabetic drugs (metformin, insulin), medications used to treat erectile dysfunction (sildenafil), medicines used to lower cholesterol levels (simvastatin), immunosuppressants (cyclosporine), and other anti-hypertensive medicines (atenolol, aliskiren, enalapril, lisinopril, ramipril, metoprolol), pain killers (ibuprofen), medicines for treating stomach ulcers (carbenoxolone).
Drug-food Interactions: Olmesartan Medoxomil+amlodipine+hydrochlorothiazide may interact with high potassium-containing food and drinks. So, if you are using any of the OTC items, please tell your doctor. Also, alcohol should not be consumed while taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide.
Drug-Disease Interactions: The efficacy of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide is affected, and the disease condition may even worsen if taken in patients with a recent or history of heart attack, low blood pressure, low potassium level, low electrolytes (sodium, potassium, calcium, etc.), anuria (non-passage of urine), angioedema (an allergic condition with swelling under the skin), lupus (an autoimmune disease), kidney disease, liver disease, asthma, diabetes.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol and Olmesartan Medoxomil+amlodipine+hydrochlorothiazide to avoid unpleasant side effects like drowsiness, dizziness, and liver damage.
Pregnancy
unsafeOlmesartan Medoxomil+amlodipine+hydrochlorothiazide is not recommended during pregnancy as it contains Olmesartan, which is a category D pregnancy drug. This medicine may cause fetal damage and can affect the unborn baby (fetus).
Breast Feeding
unsafeOlmesartan Medoxomil+amlodipine+hydrochlorothiazide is known to pass breast milk, but its effect on the baby is unknown. So, before breastfeeding, let your doctor know about this. Either you need to stop breastfeeding for using Olmesartan Medoxomil+amlodipine+hydrochlorothiazide or stop taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide.
Driving
cautionDrive with caution; Olmesartan Medoxomil+amlodipine+hydrochlorothiazide usually causes drowsiness and affects driving ability.
Liver
cautionOlmesartan Medoxomil+amlodipine+hydrochlorothiazide to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
Kidney
cautionOlmesartan Medoxomil+amlodipine+hydrochlorothiazide to be taken with caution, especially if you have had a history of kidney disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
Children
cautionEfficacy and safety of Olmesartan Medoxomil+amlodipine+hydrochlorothiazide have not been established in children. If prescribed, it should be strictly under medical supervision and only if the benefits outweigh the harm.
Habit Forming
Diet & Lifestyle Advise
- Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
- Keep your weight under control with a BMI of 19.5-24.9.
- Avoid chronic stress, as it can raise your blood pressure.
- Spend time with your loved ones to cope with stress and practice mindfulness techniques.
- Be mindful of salt; consume no more than 2,300 mg each day.
- Limit or avoid alcohol consumption.
- Quitting smoking is the best strategy to lower the risk of heart disease.
Patients Concern
Disease/Condition Glossary
Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force our heart uses to pump blood to all body parts. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). High blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.
FAQs
Olmesartan Medoxomil+amlodipine+hydrochlorothiazide is a combination of three medicines: Olmesartan medoximil, Amlodipine, and Hydrochlorothiazide. Olmesartan medoximil relaxes and widens the narrowed blood vessels. Amlodipine reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Hydrochlorothiazide is a diuretic or water pill that removes extra water/fluid and certain electrolyte overload from the body. Together, Olmesartan Medoxomil+amlodipine+hydrochlorothiazide lowers fluid overload, raises blood pressure, improves blood flow, and reduces the future risk of a heart attack and stroke.
Olmesartan Medoxomil+amlodipine+hydrochlorothiazide can be safely taken as long as your doctor prescribes it. Conditions such as high blood pressure are life-long conditions, and one should not abruptly discontinue it without discussing it with a doctor. Discontinuing Olmesartan Medoxomil+amlodipine+hydrochlorothiazide may lead to increased blood pressure and a high risk of heart attack and stroke.
It's unlikely that Olmesartan Medoxomil+amlodipine+hydrochlorothiazide affects fertility in men or women. However, in some cases, some water pills like hydrochlorothiazide may lead to erectile dysfunction. For the best advice, please consult your doctor.
Please inform your doctor before surgery if you are taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide as it needs to be stopped because it might lower the blood pressure further if taken along with local anaesthesia.
Do not use Olmesartan Medoxomil+amlodipine+hydrochlorothiazide if you are pregnant, planning for pregnancy, or unable to urinate. If you have diabetes and taking Olmesartan Medoxomil+amlodipine+hydrochlorothiazide with other blood pressure-lowering pills like 'aliskiren', immediately stop taking both together and consult a doctor.
High blood pressure during pregnancy is called 'Pregnancy-induced hypertension (PIH). It is harmful to both the baby and the mother. In the mother, very high blood pressure can cause seizures (fits), headache, swelling of feet, kidney damage, and a higher risk of bleeding during pregnancy and delivery. This can also affect the baby by causing abnormal fetal heart rate, risk of stillbirth, and a small baby. So, during pregnancy, you should have regular blood pressure monitoring. Visit your Obstetrician if you have any concerns about blood pressure during pregnancy.
Yes, Olmesartan Medoxomil+amlodipine+hydrochlorothiazide is known to cause ankle swelling (oedema) upon long-term use as Olmesartan Medoxomil+amlodipine+hydrochlorothiazide amlodipine. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.
