Olmesartan Medoxomil+cilnidipine+chlorthalidone
About
Olmesartan Medoxomil+cilnidipine+chlorthalidone belongs to the class of medicines called hypertensives primarily used to treat hypertension (high blood pressure). Hypertension or high blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it leads to heart diseases, irregular heartbeat, and other complications.
Olmesartan Medoxomil+cilnidipine+chlorthalidone is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water, certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.
Take Olmesartan Medoxomil+cilnidipine+chlorthalidone with food or as advised by the doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on the dose and duration based on your medical condition. You may experience headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Olmesartan Medoxomil+cilnidipine+chlorthalidone do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase the risk of getting stroke and heart diseases. Olmesartan Medoxomil+cilnidipine+chlorthalidone should be taken with caution in patients with chest pain (angina), kidney disease, heart failure, low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart). If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Olmesartan Medoxomil+cilnidipine+chlorthalidone can be prescribed accordingly. Do not use Olmesartan Medoxomil+cilnidipine+chlorthalidone if you cannot urinate, are dehydrated, and increase fluid intake. Please inform your doctor if you are taking any other medicines or are allergic to this medicine. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.
Uses of Olmesartan Medoxomil+cilnidipine+chlorthalidone
Medicinal Benefits
Olmesartan Medoxomil+cilnidipine+chlorthalidone is a combination of three medicines, namely: Olmesartan medoxomil, Clindipine, and Chlorthalidone, which together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. Chlorthalidone is a diuretic that removes extra water, certain electrolytes from the body and efficiently reduces blood pressure.
Directions for Use
Storage
Side Effects of Olmesartan Medoxomil+cilnidipine+chlorthalidone
- Dizziness
- Headache
- Peripheral oedema (swelling of legs/hands)
- Flushing (skin reddening)
- Rash
- Taste change
- Upset stomach
In-Depth Precautions and Warning
Drug Warnings
Olmesartan Medoxomil+cilnidipine+chlorthalidone should not be given to the people allergic to Olmesartan Medoxomil+cilnidipine+chlorthalidone, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Olmesartan Medoxomil+cilnidipine+chlorthalidone can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking Olmesartan Medoxomil+cilnidipine+chlorthalidone and breastfeeding. Grapefruit juice and St. John's wort plant should not be consumed when taking Olmesartan Medoxomil+cilnidipine+chlorthalidone as it is contraindicated. Olmesartan Medoxomil+cilnidipine+chlorthalidone contain hydrochlorothiazide which can cause hypokalaemia (low potassium), hyponatremia (low sodium) and hypomagnesemia (low magnesium). So regular monitoring of electrolytes is required while taking treatment with Olmesartan Medoxomil+cilnidipine+chlorthalidone. Do not take Olmesartan Medoxomil+cilnidipine+chlorthalidone if you have low or no urine output, allergic to other sulfonamide antibiotics, or taking aliskiren and have diabetes. Drinking alcohol while using Olmesartan Medoxomil+cilnidipine+chlorthalidone can cause you to have low blood pressure, so avoid intake of alcoholic beverages.
Drug Interactions
Drug-Drug Interaction: Olmesartan Medoxomil+cilnidipine+chlorthalidone may interact with other high blood pressure-lowering pills (benazepril, metoprolol, ramipril, hydrochlorothiazide, simvastatin, diltiazem, aliskiren, verapamil, azilsartan, benazepril, lisinopril, amiloride), and can lower your blood pressure leading to severe condition. Besides this, medicine to treat erectile dysfunction (sildenafil), antibiotics (clarithromycin, erythromycin), anti TB drug (rifampicin), antifungal (itraconazole, ketoconazole), anti-HIV drugs (ritonavir), anti-epilepsy medicines (carbamazepine, phenytoin, phenobarbital, primidone), antibiotics (erythromycin), immune-suppressing drugs (cyclosporine, tacrolimus), and pain killers (ibuprofen, aspirin) should not be taken with Olmesartan Medoxomil+cilnidipine+chlorthalidone.
Drug-Food Interaction: Olmesartan Medoxomil+cilnidipine+chlorthalidone severely interacts with grapefruit, grapefruit juices, and St. John’s wort (a plant used to treat depression). Hence it should not be taken with Olmesartan Medoxomil+cilnidipine+chlorthalidone.
Drug-Disease Interaction: Olmesartan Medoxomil+cilnidipine+chlorthalidone should not be given to the people with electrolytes problem (low potassium, low magnesium or low sodium), chest pain (angina), cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problem (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, kidney problem, or heart failure.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeOlmesartan Medoxomil+cilnidipine+chlorthalidone can lower your blood pressure causing dizziness and drowsiness. It can also cause orthostatic hypotension (sudden fall in blood pressure while standing). So try to avoid intake of Olmesartan Medoxomil+cilnidipine+chlorthalidone with alcoholic beverages.
Pregnancy
unsafeOlmesartan Medoxomil+cilnidipine+chlorthalidone is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Olmesartan Medoxomil+cilnidipine+chlorthalidone as soon as possible and consult the doctor.
Breast Feeding
cautionOlmesartan Medoxomil+cilnidipine+chlorthalidone passes into the breast milk. But its effect on the baby is not clear. However, it is advisable to contact the doctor before intake of Olmesartan Medoxomil+cilnidipine+chlorthalidone.
Driving
unsafeOlmesartan Medoxomil+cilnidipine+chlorthalidone may cause side effects which could affect your ability to drive. Taking Olmesartan Medoxomil+cilnidipine+chlorthalidone may lower your blood pressure.
Liver
cautionOlmesartan Medoxomil+cilnidipine+chlorthalidone to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
Kidney
cautionNot recommended in patients with chronic kidney disease (severe renal impairment). Safety and effectiveness in patients with severe renal impairment have not been established.
Children
unsafeOlmesartan Medoxomil+cilnidipine+chlorthalidone is not recommended in children. The safety and efficacy of Olmesartan Medoxomil+cilnidipine+chlorthalidone in children have not yet been established.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with BMI 19.5-24.9.
- Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
- Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
- Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
- If you are taking alcohol, then only one serving for women and two servings is advisable.
- Quitting smoking is the best strategy to lower the risk of heart disease.
- Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
- Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.
Special Advise
Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
Patients Concern
Disease/Condition Glossary
Blood pressure: It is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.
FAQs
It is advised to continue your medicine even after your blood pressure is under control or becomes normal as blood pressure can shoot up at any time. If you have a persistent headache, please consult your doctor immediately.
In case you have missed a dose of Olmesartan Medoxomil+cilnidipine+chlorthalidone, you are advised to take it as soon as you remember. However, try not to miss a dose in the first place; if it's time for you to take your next dose, then do not take both the doses together. Take only one dose; taking a double dose of Olmesartan Medoxomil+cilnidipine+chlorthalidone will lead to low blood pressure.
Yes, Olmesartan Medoxomil+cilnidipine+chlorthalidone is contraindicated in people with known allergy to any of this medicine's components. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.
Yes, Olmesartan Medoxomil+cilnidipine+chlorthalidone can cause dry mouth. Therefore, it is always advised to increase fluid intake while taking Olmesartan Medoxomil+cilnidipine+chlorthalidone. If you still feel excessively thirsty, please consult your doctor and advise for the best results of Olmesartan Medoxomil+cilnidipine+chlorthalidone.
It's unlikely that Olmesartan Medoxomil+cilnidipine+chlorthalidone affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There's not enough evidence to say for certain. For the best advice, consult your doctor.
Yes, Olmesartan Medoxomil+cilnidipine+chlorthalidone is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.
Yes, Olmesartan Medoxomil+cilnidipine+chlorthalidone can cause an upset stomach. So, it is preferred to take Olmesartan Medoxomil+cilnidipine+chlorthalidone with food to avoid it.
High blood pressure in the pregnancy stage may cause eclampsia that can be harmful to both baby and mother. So, during the pregnancy, you should have regular blood pressure monitoring.
Olmesartan Medoxomil+cilnidipine+chlorthalidone if stopped abruptly can lead to withdrawal symptoms. So, before stopping Olmesartan Medoxomil+cilnidipine+chlorthalidone, consult your doctor; your dose will be lowered gradually to avoid unpleasant side effects of Olmesartan Medoxomil+cilnidipine+chlorthalidone.
