Protamine Sulphate
About
Protamine Sulphate is indicated in the treatment of heparin overdose. It is used before surgery, after open-heart surgery, and after kidney dialysis if too much heparin has been given by accident or if you bleed during heparin treatment.
Protamine Sulphate contains Protamine sulphate, a heparin antidote that works by neutralising the anti-blood-clotting effect of heparin and preventing it from thinning the blood too much.
In some cases, Protamine Sulphate may cause side effects such as nausea, vomiting, tiredness, bleeding, and back pain. You are advised to talk to your doctor if any of the side effects persist or worsen.
Let your doctor know if you are allergic to any of the components in Protamine Sulphate. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your health condition and medications to rule out any side effects/interactions.
Uses of Protamine Sulphate
Medicinal Benefits
Protamine Sulphate is indicated in the treatment of heparin overdosage. It is used to counteract the effect of heparin before surgery, after open-heart surgery, after renal dialysis or if excessive bleeding occurs. Protamine Sulphate contains Protamine sulphate, a heparin antidote that works by neutralising the anti-blood-clotting effect of heparin and preventing it from thinning the blood too much.
Directions for Use
Storage
Side Effects of Protamine Sulphate
- Nausea
- Vomiting
- Tiredness
- Back pain
In-Depth Precautions and Warning
Drug Warnings
Do not take Protamine Sulphate if you are allergic to any of its components. Inform your doctor if you are allergic to fish, have had heart surgery, are an insulin-dependent diabetic, or if you are a man who is infertile or have undergone vasectomy (an operation that makes a man sterile). Consult your doctor if you are pregnant or breastfeeding. Let your doctor know if you are taking any other medicines.
Drug Interactions
Drug-Drug Interactions: Inform your doctor if you are taking antibiotics, including cephalosporins and penicillins.
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: No interactions found/established.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if alcohol affects Protamine Sulphate. Please consult your doctor.
Pregnancy
cautionIf you are pregnant or planning pregnancy, inform your doctor before receiving Protamine Sulphate.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before receiving Protamine Sulphate.
Driving
safe if prescribedProtamine Sulphate has not been reported to affect your ability to drive. However, drive or operate machinery only if you are alert.
Liver
consult your doctorInform your doctor if you have a history of liver disease before receiving Protamine Sulphate.
Kidney
consult your doctorInform your doctor if you have a history of kidney disease before receiving Protamine Sulphate.
Children
unsafeProtamine Sulphate is not recommended in children as safety and effectiveness have not been established.
Habit Forming
Patients Concern
Disease/Condition Glossary
Heparin overdose: Heparin overdose might occur when an overdose of heparin may be given accidentally. In a heparin overdose, the body is unable to deploy its natural defence against excessive bleeding. Symptoms include nosebleeds, blood in urine, black/tarry stools, unusual bleeding, internal bleeding, and easy bruising.
FAQs
Protamine Sulphate works by neutralising the anti-blood-clotting effect of heparin and preventing it from thinning the blood too much.
Protamine sulphate may be obtained from the sperm of salmon and other species of fish. Therefore, inform your doctor if you are allergic to fish.
Protamine Sulphate may cause low blood pressure. If you feel dizzy, faint or blackout, consult your doctor.
