Rabeprazole Sodium+domperidone
About
Rabeprazole Sodium+domperidone belongs to a group of medicines called gastrointestinal agents used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, the fullness of stomach, bloating, gas, helicobacter pylori infection, gastric and duodenal ulcers. Acidity occurs when the gastric glands produce more stomach acid required for digestion.
Rabeprazole Sodium+domperidone is a combination of two drugs: Rabeprazole sodium (proton pump inhibitor) and Domperidone (a dopamine antagonist). Rabeprazole sodium works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of the stomach muscle. Together, Rabeprazole Sodium+domperidone helps in treating acidity-related problems.
Take Rabeprazole Sodium+domperidone 30-60minutes prior to food. Depending on your medical condition, you are advised to take Rabeprazole Sodium+domperidone for as long as your doctor has prescribed it for you. Sometimes, you may experience common side effects such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Inform your doctor before taking Rabeprazole Sodium+domperidone if you have a history of gastrointestinal bleeding or intestinal obstruction. Talk to your doctor before taking Rabeprazole Sodium+domperidone if you have osteoporosis as Rabeprazole Sodium+domperidone may increase the risk of bone fractures on long-term treatment. Consult your doctor before taking Rabeprazole Sodium+domperidone if you are pregnant or breastfeeding. Rabeprazole Sodium+domperidone may cause dizziness, so drive only if you are alert. Rabeprazole Sodium+domperidone should not be given to children as safety has not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.
Uses of Rabeprazole Sodium+domperidone
Medicinal Benefits
Rabeprazole Sodium+domperidone is a combination of two drugs: Rabeprazole sodium and Domperidone. Rabeprazole Sodium+domperidone is used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, the fullness of the stomach, bloating, gas, helicobacter pylori infection, gastric and duodenal ulcers. Rabeprazole sodium is a proton pump inhibitor that works by blocking the action of an enzyme called gastric proton pump, which is responsible for acid production. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, Rabeprazole Sodium+domperidone helps in treating acidity-related problems.
Directions for Use
Storage
Side Effects of Rabeprazole Sodium+domperidone
- Dry mouth
- Stomach pain
- Diarrhoea
- Headache
- Flatulence
In-Depth Precautions and Warning
Drug Warnings
Do not take Rabeprazole Sodium+domperidone if you are allergic to any of its contents; if you are taking atazanavir (used to treat HIV); if you have galactose intolerance, lactase deficiency, glucose-galactose malabsorption, electrolyte disturbance, heart failure, or gastrointestinal haemorrhage. Inform your doctor before taking Rabeprazole Sodium+domperidone if you have stomach tumour, kidney, heart or liver disease, or if you are due to have Chromogranin A blood test. On long-term treatment, Rabeprazole Sodium+domperidone may cause low magnesium levels, and vitamin B12 levels, and increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Consult your doctor if you are pregnant or breastfeeding. Prolonged intake of Rabeprazole Sodium+domperidone is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that persists or worsens, immediately consult a doctor.
Drug Interactions
Drug-Drug Interactions: Rabeprazole Sodium+domperidone may have interaction with anti-HIV (atazanavir, nelfinavir, saquinavir), blood thinner (clopidogrel, warfarin), a drug used to treat hypothyroidism (levothyroxine), anti-rheumatoid (methotrexate), anti-depressant (duloxetine), vitamin (cyanocobalamin), cardiac glycoside (digoxin).
Drug-Food Interactions: Rabeprazole Sodium+domperidone may interact with St.John’s wort (herbal supplement used to treat depression). Avoid alcohol consumption as alcohol intake increases stomach acid production, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Inform your doctor if you have/had epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, and hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Rabeprazole Sodium+domperidone. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Pregnancy
cautionIf you are pregnant consult your doctor before taking Rabeprazole Sodium+domperidone; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionIf you are breastfeeding, consult your doctor before taking Rabeprazole Sodium+domperidone; your doctor will decide whether Rabeprazole Sodium+domperidone can be taken by breastfeeding mothers or not.
Driving
cautionRabeprazole Sodium+domperidone may cause dizziness. Hence, do not drive or operate machinery unless you are alert after taking this medicine.
Liver
cautionRabeprazole Sodium+domperidone is contraindicated in patients with moderate to severe liver disease. If you have pre-existing liver problems, consult your doctor before taking this medicine. Your doctor may adjust the dose or may prescribe a suitable alternative based on your condition.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Rabeprazole Sodium+domperidone if you have kidney impairment or any concerns regarding this.
Children
cautionRabeprazole Sodium+domperidone is not recommended for children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight by regular exercising.
- Avoid lying down after eating as it causes acid reflux.
- Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
- Practise relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat, spicy, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes break every hour by doing brisk walking or stretching.
Special Advise
- Inform your doctor before taking Rabeprazole Sodium+domperidone if you are due to have Chromogranin A blood test.
- Rabeprazole Sodium+domperidone may cause false-positive results for urine screening tests and secretin stimulation tests. Inform the person doing the tests that you are taking Rabeprazole Sodium+domperidone.
Patients Concern
Disease/Condition Glossary
Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, the mucous layer gets eroded due to excess acid production, which leads to complications like GERD, heartburn, peptic/gastric ulcers and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, a sour or bitter taste, and difficulty swallowing. Gastric ulcers are sores that develop on the stomach and intestine lining due to erosion of the stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion. Zollinger-Ellison syndrome is characterised by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Rabeprazole Sodium+domperidone contains Rabeprazole sodium and Domperidone. Rabeprazole sodium works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of the stomach muscle. Together, Rabeprazole Sodium+domperidone helps in treating acidity.
Diarrhoea might be a side-effect of Rabeprazole Sodium+domperidone. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. Consult your doctor if you experience excessive diarrhoea or if you find blood in your stools.
Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.
Dry mouth could be a side-effect of Rabeprazole Sodium+domperidone. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help stimulate saliva and thereby prevent drying of the mouth.
Rabeprazole Sodium+domperidone contains domperidone which helps in treating nausea and vomiting by increasing the movements and contractions of stomach muscle.
Do not take Rabeprazole Sodium+domperidone for longer durations unless prescribed by the doctor. Consult your doctor if your condition does not improve even after taking Rabeprazole Sodium+domperidone for 14 days.
