Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide
About
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is a combination medicine used for the prevention of cardiovascular events and stroke. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide helps in lowering of blood pressure, heart rate, lipid levels and decreases the stickiness of platelets. Heart attack or stroke occurs due to the blockage of blood flow to the heart muscle. The blockade usually occurs due to build-up of fat/cholesterol in the coronary artery. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide lowers the risk of heart attack or stroke by controlling the blood pressure, lowering the fat and increasing HDL (good cholesterol) levels.
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide contains Simvastatin (lipid-lowering agent), Ramipril (ACE inhibitor), Atenolol (beta-blocker), Aspirin (anti-platelet) and Hydrochlorothiazide (diuretic). Simvastatin helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril relaxes the blood vessels and allows smooth blood flow. Atenolol slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide helps in removal of unneeded water and salts from the body. Aspirin decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide helps in lowering the risk of a heart attack.
You are advised to take Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as weakness, indigestion, constipation, dizziness and musculoskeletal pain. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Do not take Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Talk to a doctor immediately if you become pregnant while taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide. Consult your doctor before taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are breastfeeding. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide as it could lead to increased dizziness. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is not recommended for children as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side-effects/interactions.
Uses of Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide
Medicinal Benefits
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is a combination of five drugs, namely: Simvastatin, Ramipril, Atenolol, Aspirin, and Hydrochlorothiazide. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is used for the prevention of cardiovascular events and stroke. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide helps in lowering of blood pressure, heart rate, lipid levels, and decreases the stickiness of platelets. Simvastatin is a lipid-lowering agent that helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril, Atenolol and Hydrochlorothiazide help in controlling blood pressure. Ramipril is an ACE inhibitor which relaxes the blood vessels and allows smooth blood flow. Atenolol is a beta-blocker that slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide is a diuretic that helps remove unneeded water and salts from the body. Aspirin is an anti-platelet agent that decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide helps in lowering the risk of a heart attack. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide lowers the risk of heart attack or stroke by controlling blood pressure, lowering fat and increasing HDL levels.
Directions for Use
Storage
Side Effects of Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide
- Weakness
- Indigestion
- Constipation
- Dizziness
- Musculoskeletal pain
In-Depth Precautions and Warning
Drug Warnings
Do not take Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are allergic to any of its contents, if you are taking fusidic acid or sacubitril. Inform your doctor if you are due to have surgery, drink large amounts of alcohol, if you have asthma, diabetes, overactive thyroid, pheochromocytoma (tumour of the adrenal gland), gout, glaucoma, stomach or intestinal bleeding or bleeding disorders, stomach ulcers, liver or kidney problems. Do not take Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Talk to a doctor immediately if you become pregnant while taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide. Consult your doctor before taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are breastfeeding. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide as it could lead to increased dizziness. Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is not recommended for children as safety and effectiveness have not been established.
Drug Interactions
Drug-Drug Interactions: Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide may interact with antibiotic (fusidic acid, erythromycin), antacid (esomeprazole), hormone (levothyroxine), anti-convulsant (pregabalin), diuretic (furosemide), anti-diabetic (sitagliptin, insulin glargine), anti-hypertensive (amlodipine, metoprolol), anti-anxiety (alprazolam), supplements (calcium, vitamin D, cholecalciferol), anti-depressant (duloxetine), blood thinner (clopidogrel).
Drug-Food Interactions: Avoid consuming grapefruit and grapefruit juice with Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide. Do not take St. John’s wort (herbal supplement to treat depression) with Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide.
Drug-Disease Interactions: Inform your doctor if you have rhabdomyolysis (muscle breakdown), Reye’s syndrome, asthma, gout, glaucoma, liver disease, diabetes or cognitive impairment.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide as it may cause increased dizziness.
Pregnancy
unsafeDo not take Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Consult a doctor immediately if you become pregnant while taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide.
Breast Feeding
cautionConsult your doctor before taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide; your doctor will decide whether Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide can be taken by breastfeeding mothers or not.
Driving
cautionSimvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide may cause dizziness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionSimvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is not recommended for children as the safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Follow a cholesterol-lowering diet.
- Consume low-salt and a low-fat diet.
- Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
- Limit salt and sugar intake.
- Avoid smoking and alcohol consumption.
- Choose healthy fats and cut down on trans-fat.
- Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
- Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.
Special Advise
- Regular blood tests are advised to determine the effect of Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide on lipids.
- Consult your doctor immediately if you experience muscle pain, weakness, or tenderness, especially if associated with fever or tiredness.
- Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide might affect test results for liver function and muscle enzyme (creatin-kinase). Inform the person doing the tests that you are taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide.
- It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke.
- Regularly monitor blood pressure levels, heart rate and electrolyte levels.
Patients Concern
Disease/Condition Glossary
Heart attack: Heart attack or stroke occurs due to the blockage of blood flow to the heart muscle. The blockade usually occurs due to the build-up of fat/cholesterol in the coronary artery. High cholesterol levels might lead to a build-up of fat on the walls of the arteries leading to blockage of blood flow to the heart and other body parts, which could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely bad cholesterol and good cholesterol. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposit fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Symptoms of angina include pain or tightness in the chest, discomfort, pain in the neck, arms or back, weakness, lightheadedness and abnormal heartbeat. Risk factors include obesity, stress, smoking, high-fat diet, lack of exercise and genetics.
FAQs
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide is a combination of five drugs, namely: Simvastatin, Ramipril, Atenolol, Aspirin, and Hydrochlorothiazide. Simvastatin helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril, Atenolol, and Hydrochlorothiazide help in controlling the blood pressure. Ramipril relaxes the blood vessels and allows smooth blood flow. Atenolol slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide helps in removal of unneeded water and salts from the body. Aspirin decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide helps in lowering the risk of a heart attack.
Do not discontinue Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide without consulting your doctor as it could increase the risk of a heart attack. To treat your condition effectually, continue taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide.
Constipation could be a side-effect of Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide. Drink plenty of fluids and eat fibre rich food if you experience constipation. Consult your doctor if you have severe constipation.
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide contains aspirin, hence it should not be taken by patients with haemorrhagic stroke as it causes bleeding, which could be dangerous. Haemorrhagic stroke is a condition in which there is bleeding in the brain due to a rupture of the blood vessel.
Orthostatic hypotension could be a side-effect of Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better. People taking Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide are advised to monitor their blood pressure levels regularly to avoid such unpleasant events.
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide contains Simvastatin which helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol.
Simvastatin+ramipril+atenolol+aspirin+hydrochlorothiazide should be administered with caution in patients with increased thyroid hormone levels. Abrupt withdrawal of this medicine may lead to a life-threatening condition called thyroid storm. Your doctor may adjust the dose or suggest an alternative medication.
