Solifenacin+mirabegron
About
Solifenacin+mirabegron is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, and dysuria (painful or difficult urination). Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control.
Solifenacin+mirabegron contains Solifenacin (anti-cholinergic) and Mirabegron (beta-3 adrenergic agonist). Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Solifenacin+mirabegron helps in treating overactive bladder.
You are advised to take Solifenacin+mirabegron for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side-effects such as dry mouth, constipation, headache, high blood pressure, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Solifenacin+mirabegron is not recommended for children as safety and efficacy have not been established. Solifenacin+mirabegron may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption along with Solifenacin+mirabegron as it could lead to increased dizziness. Inform your doctor about your health condition and medications before taking Solifenacin+mirabegron to rule out any side effects/interactions.
Uses of Solifenacin+mirabegron
Medicinal Benefits
Solifenacin+mirabegron is a combination of two drugs, namely: Solifenacin and Mirabegron. Solifenacin+mirabegron is a combination medicine used to treat overactive bladder (OAB) with symptoms of urinary incontinence (urine leakage), urgent or frequent urination, increased night-time urination, dysuria (painful or difficult urination). Solifenacin is an anti-cholinergic that reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron is a beta-3 adrenergic agonist which relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Solifenacin+mirabegron helps in treating an overactive bladder.
Directions for Use
Storage
Side Effects of Solifenacin+mirabegron
- Constipation
- Headache
- Dry mouth
- Blurred vision
- Vomiting
- High blood pressure
- Urinary tract infection
In-Depth Precautions and Warning
Drug Warnings
Do not take Solifenacin+mirabegron if you are allergic to any of its contents. Inform your doctor if you have glaucoma, myasthenia gravis, ulcerative colitis, urinary retention, high blood pressure, angioedema, kidney or liver problems. Consult your doctor if you are pregnant or breastfeeding. Solifenacin+mirabegron is not recommended for children. Solifenacin+mirabegron may cause blurred vision, so drive with caution. Avoid or limit alcohol consumption with Solifenacin+mirabegron as it could lead to increased dizziness.
Drug Interactions
Drug-Drug Interactions: Solifenacin+mirabegron may interact with antihistamine (diphenhydramine), analgesic (acetaminophen), bronchodilator (albuterol), beta-blocker (metoprolol).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have glaucoma, urinary obstruction/retention, high blood pressure, kidney or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionYou are recommended to avoid or limit alcohol consumption while taking Solifenacin+mirabegron as it may cause increased dizziness.
Pregnancy
cautionLimited information is available regarding the usage of Solifenacin+mirabegron during pregnancy. Consult your doctor before taking Solifenacin+mirabegron if you are pregnant.
Breast Feeding
cautionLimited information is available regarding the usage of Solifenacin+mirabegron during breastfeeding. Consult your doctor before taking Solifenacin+mirabegron if you are breastfeeding.
Driving
cautionSolifenacin+mirabegron may cause blurred vision and tiredness. Drive or operate machinery only if you are alert.
Liver
cautionPlease consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionPlease consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionSolifenacin+mirabegron is not recommended for children as safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
- Pelvic floor exercises would be helpful in treating bladder spasms.
- Avoid foods like sugars, carbonated beverages, tea, citrus fruits, tomatoes, spicy foods, chocolate and tea.
- Avoid drinking excess alcohol or caffeinated drinks, as they can worsen the symptoms.
- Maintain a healthy weight, and exercise regularly.
- Quit smoking.
- Take 6-8glasses of liquids every day.
- Avoid processed foods. Instead, choose whole, unprocessed foods.
- Include fruits, vegetables, and fibre-rich food in your diet.
Patients Concern
Disease/Condition Glossary
Overactive bladder (OAB): Overactive bladder is a condition in which there is a problem with bladder function, which causes a sudden urge to urinate that might be difficult to control. The contraction or tightening of bladder muscles causes bladder spasms. Continuous contractions may cause an urge to urinate. Overactive bladder is characterised by involuntary leakage of urine, excessive urination, and urgent need to urinate. The common causes of bladder spasms are urinary tract infections, drinking too much caffeine or alcohol, diabetes, constipation, impaired kidney function, bladder stones, enlarged prostate, or neurological disorders. Symptoms of overactive bladder include urinating more than 8 times a day and more than 2 times at night, strong and sudden need to urinate, leakage of urine, and loss of bladder control.
FAQs
Solifenacin+mirabegron contains Solifenacin and Mirabegron. Solifenacin reduces the undesirable contractions of the bladder, thereby increasing the amount of urine that the bladder can hold. This decreases the urgency for urination. Mirabegron relaxes the muscles of the bladder; this prevents frequent, uncontrolled, or urgent urination. Together, Solifenacin+mirabegron helps in treating an overactive bladder.
There is some overlap between the symptoms of both OAB and BPH. OAB occurs due to uncontrolled urinary bladder muscle contractions. The main symptom of OAB is a sudden urge to urinate that's hard to control, which is stressful. On the other hand, BPH occurs due to an enlarged prostate gland, which puts pressure on the urinary bladder, thereby causing pain during urination.
Dry mouth could be a side effect of Solifenacin+mirabegron. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol; drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Solifenacin+mirabegron might cause hypertension. Therefore, consult your doctor before taking Solifenacin+mirabegron if you have high blood pressure.
Constipation could be a side-effect of Solifenacin+mirabegron. Eat fibre-rich food and drink plenty of fluids if you experience constipation. Talk to your doctor if you have severe constipation.
