Tizanidine+aceclofenac+paracetamol
About
Tizanidine+aceclofenac+paracetamol belongs to the class of medications called 'non-steroidal anti-inflammatory drugs (NSAID)' used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone, joint pain, headache, and period pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.
Tizanidine+aceclofenac+paracetamol contains Tizanidine (muscle relaxant), Aceclofenac (pain killer), and Paracetamol (mild analgesic and fever reducer). Tizanidine works on the brain's centres, thereby helping to relieve muscle stiffness and improve muscle movements. Aceclofenac and Paracetamol work by blocking chemical messengers that cause pain and inflammation at the injured or damaged site. Together, Tizanidine+aceclofenac+paracetamol helps in relieving pain due to muscle spasms.
You are advised to take Tizanidine+aceclofenac+paracetamol for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as nausea, vomiting, stomach pain, loss of appetite, heartburn, and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Tizanidine+aceclofenac+paracetamol may cause drowsiness and dizziness, so drive with caution. Tizanidine+aceclofenac+paracetamol should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol as it may cause increased drowsiness, dizziness and increased risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.
Uses of Tizanidine+aceclofenac+paracetamol
Medicinal Benefits
Tizanidine+aceclofenac+paracetamol is a combination of three drugs, namely: Tizanidine, Aceclofenac, and Paracetamol. Tizanidine+aceclofenac+paracetamol is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, headache, and period pain. Tizanidine is a muscle relaxant which works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol are analgesics which work by blocking the effect of a chemical messenger known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. Prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, Tizanidine+aceclofenac+paracetamol helps in relieving pain and fever due to muscle spasms.
Directions for Use
Storage
Side Effects of Tizanidine+aceclofenac+paracetamol
- Nausea
- Vomiting
- Stomach pain
- Diarrhoea
- Loss of appetite
- Heartburn
In-Depth Precautions and Warning
Drug Warnings
Do not take Tizanidine+aceclofenac+paracetamol if you are allergic to any of its contents; if you have/had severe heart problems, stomach ulcer or perforation, and bleeding problems such as bleeding from the stomach, intestine or brain, bypass surgery, heart attack, blood circulation problems, or inflammation of intestines. Inform your doctor if you have or had high blood pressure, heart problems, high cholesterol, diabetes, asthma, inflammatory bowel disease, liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Tizanidine+aceclofenac+paracetamol may cause drowsiness and dizziness, so drive only if you are alert. Tizanidine+aceclofenac+paracetamol is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol along with Tizanidine+aceclofenac+paracetamol as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Stop taking Tizanidine+aceclofenac+paracetamol and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Tizanidine+aceclofenac+paracetamol unless prescribed.
Drug Interactions
Drug-Drug Interactions: Tizanidine+aceclofenac+paracetamol may interact with pain killers (aspirin, ibuprofen, naproxen, celecoxib, etoricoxib, hydrocodone), anti-depressants (citalopram, escitalopram, duloxetine, fluoxetine, fluvoxamine, paroxetine, sertraline, lithium), cardiac glycoside (digoxin), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine, propranolol), antibiotics (ciprofloxacin, ofloxacin, levofloxacin moxifloxacin), diuretics (furosemide, amiloride hydrochloride), blood thinners (warfarin, heparin, clopidogrel), anti-rheumatoid (methotrexate), steroids (mifepristone), glucocorticoids (hydrocortisone, prednisolone), immunosuppressants (ciclosporin, tacrolimus), anti-HIV (zidovudine), anti-diabetic (glibenclamide, gliclazide, tolbutamide), hypnotic (zolpidem), anti-convulsant (pregabalin), antihistamine (diphenhydramine, cetirizine)
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anaemia, heart, kidney or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Tizanidine+aceclofenac+paracetamol as it may cause increased drowsiness.
Pregnancy
cautionPlease consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Tizanidine+aceclofenac+paracetamol; your doctor will decide whether Tizanidine+aceclofenac+paracetamol can be taken by breastfeeding mothers or not.
Driving
cautionTizanidine+aceclofenac+paracetamol may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeTizanidine+aceclofenac+paracetamol should not be given to children as safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
- Massages can also be helpful.
- Avoid freezing and hot temperatures.
- Avoid wearing tight-fitting clothes, instead, wear loose garments.
- Rest well, get plenty of sleep.
- To avoid developing pressure sores, change your position at least every two hours.
- Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
- Stay hydrated, drink plenty of water.
Special Advise
- Stop taking Tizanidine+aceclofenac+paracetamol if you experience stomach discomfort or heartburn, vomiting blood or passing black stools, skin troubles such as rash or itching, wheezing or shortness of breath, or yellowing of your skin or the whites of your eyes.
Patients Concern
Disease/Condition Glossary
Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute or chronic, can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles, and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, soreness, cracking or popping sound at the joints.
FAQs
Tizanidine+aceclofenac+paracetamol contains Tizanidine, Aceclofenac, and Paracetamol. Tizanidine is a muscle relaxant which works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements. Aceclofenac and Paracetamol are analgesics which work by blocking chemical messengers that cause pain and inflammation at the injured or damaged site.
Tizanidine+aceclofenac+paracetamol is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.
Diarrhoea might be a side-effect of Tizanidine+aceclofenac+paracetamol. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Tizanidine+aceclofenac+paracetamol should not be taken for longer durations unless prescribed by the doctor. If Tizanidine+aceclofenac+paracetamol has been prescribed for longer durations, regular monitoring of kidney function, liver function, and blood count is advised, particularly in elderly patients.
Dry mouth could be a side-effect of Tizanidine+aceclofenac+paracetamol. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevents drying of the mouth.
Taking Tizanidine+aceclofenac+paracetamol can elevate symptoms of gastric ulcer and bleeding. So, talk to your doctor before taking Tizanidine+aceclofenac+paracetamol if you have stomach ulcers, gastrointestinal bleeding or other bleeding problems like haemophilia.
