Tramadol+acetaminophen
About
Tramadol+acetaminophen belongs to a class of drugs called analgesics (pain killers) primarily used to treat moderate to severe pain. Pain is an unpleasant sensation caused by an injury or illness. Pain may be acute (short term) or chronic (long term). It can be general (overall body pains) or localized (pain in a specific area of the body).
Tramadol+acetaminophen is a combination of two drugs, namely: Tramadol (opioid analgesic) and Acetaminophen (analgesic and antipyretic). Tramadol works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever.
Take Tramadol+acetaminophen as prescribed by your doctor. You are advised to take Tramadol+acetaminophen for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience drowsiness, nausea, dizziness, headache, vomiting, dry mouth, constipation, excessive sweating, shaking, confusion or mood changes. Most of these side effects of Tramadol+acetaminophen do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.
If you are allergic to Tramadol+acetaminophen or any other medicines, please tell your doctor. Tramadol+acetaminophen is not recommended for children below 12 years of age, as the safety and effectiveness were not established. Avoid taking Tramadol+acetaminophen if you are pregnant as it may cause withdrawal symptoms in the newborn baby. Tramadol+acetaminophen may be excreted in human milk. Please consult a doctor if you are breastfeeding. It is an offence to drive if Tramadol+acetaminophen affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking Tramadol+acetaminophen. Avoid alcohol consumption with Tramadol+acetaminophen as it may increase drowsiness.
Uses of Tramadol+acetaminophen
Medicinal Benefits
Tramadol+acetaminophen is a combination of two drugs: Tramadol and Acetaminophen to treat moderate to severe pain. Tramadol mimics the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby inhibits the transmission of pain signals from nerves to brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that inhibits the production of certain chemical messengers in the brain known as prostaglandins responsible for pain and fever.
Directions for Use
Storage
Side Effects of Tramadol+acetaminophen
- Drowsiness
- Nausea
- Dizziness
- Headache
- Vomiting
- Dry mouth
- Constipation
- Excessive sweating
- Shaking
- Confusion
- Mood changes
In-Depth Precautions and Warning
Drug Warnings
If you are allergic to Tramadol+acetaminophen or any other medicines, please tell your doctor. Tramadol+acetaminophen is not recommended for children below 12 years of age, as the safety and effectiveness were not established. Avoid taking Tramadol+acetaminophen if you are pregnant as it may cause withdrawal symptoms in the newborn baby. Tramadol+acetaminophen may be excreted in human milk. Please consult a doctor if you are breastfeeding. If you have fits, asthma, severe lung problems, drug dependence, liver or kidney problems, inform your doctor before taking Tramadol+acetaminophen. It is an offence to drive if Tramadol+acetaminophen affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking Tramadol+acetaminophen. Avoid alcohol consumption with Tramadol+acetaminophen as it may increase drowsiness. Do not take Tramadol+acetaminophen if you are taking pain relievers, sleeping pills, or taking medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Inform your doctor immediately if you experience any sleep-related breathing problems such as sleep apnoea (breathing stops and starts repeatedly) while taking Tramadol+acetaminophen.
Drug Interactions
Drug-Drug Interactions: Tramadol+acetaminophen may interact with anticonvulsants (carbamazepine, pregabalin), opioid pain killers (pentazocine, buprenorphine, nalbuphine, morphine), cough medication (codeine), muscle relaxant (baclofen), blood thinners (warfarin, phenprocoumon), antiemetic drugs (ondansetron, metoclopramide, domperidone), high cholesterol lowering medicine (cholestyramine), sedative-hypnotics (zolpidem), pain relievers (celecoxib), antidepressants (duloxetine, escitalopram), and anti-anxiety drugs (alprazolam).
Drug- Food Interactions: Avoid foods rich in carbohydrates, pectin including jellies, cabbage, Brussels sprouts and broccoli as Tramadol+acetaminophen may interact with these foods. Tramadol+acetaminophen may interact with grapefruit juice. Therefore, avoid intake of grapefruit juice with Tramadol+acetaminophen as it may increase Tramadol+acetaminophen levels in the body. Also, avoid alcohol consumption while taking Tramadol+acetaminophen as it may increase drowsiness.
Drug-Disease Interactions: If you have fits, asthma, severe lung problems, severe headaches associated with vomiting, drug dependence, liver or kidney problems or if you have recently suffered from shock or head injury, inform your doctor before taking Tramadol+acetaminophen.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol with Tramadol+acetaminophen as it may cause drowsiness.
Pregnancy
unsafeTramadol+acetaminophen is not recommended for pregnant women as it may cause withdrawal symptoms in the newborn baby. However, please consult your doctor if you are pregnant.
Breast Feeding
cautionTramadol+acetaminophen may be excreted in breast milk and cause adverse effects in the baby. However, please consult a doctor if you are breastfeeding.
Driving
unsafeTramadol+acetaminophen may cause dizziness or drowsiness in some people. It is an offence to drive if Tramadol+acetaminophen affects you. Therefore, avoid driving if you feel drowsy or dizzy after taking Tramadol+acetaminophen.
Liver
cautionTake Tramadol+acetaminophen with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Tramadol+acetaminophen if you have severe liver insufficiency.
Kidney
cautionTake Tramadol+acetaminophen with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Avoid taking Tramadol+acetaminophen if you have severe kidney insufficiency.
Children
unsafeTramadol+acetaminophen is not recommended for children below 12 years of age, as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Do regular exercises such as swimming or walking.
- Drink plenty of water while taking Tramadol+acetaminophen to avoid dry mouth.
- Maintain a fibre rich diet and eat plenty of fresh fruits and vegetables to avoid constipation while taking Tramadol+acetaminophen.
- Avoid consumption of alcohol and quit smoking.
Special Advise
- Patients with severe liver or kidney insufficiency should avoid taking Tramadol+acetaminophen.
- Do not give Tramadol+acetaminophen to others. Use Tramadol+acetaminophen only when prescribed by a doctor and avoid frequent or high doses as it may cause addiction.
- Please do not stop taking Tramadol+acetaminophen suddenly as it may cause withdrawal symptoms such as difficulty in sleeping, anxiety, nervousness, shaking, stomach or bowel disorders or make you overactive. Therefore, take Tramadol+acetaminophen for as long as your doctor has prescribed it.
Patients Concern
Disease/Condition Glossary
Pain is an unpleasant sensation caused by an injury or illness. Pain may be acute (short term) or chronic (long term). It can be general (overall body pains) or localized (pain in a specific area of the body). Pain is highly subjective as some people have a high tolerance for pain while others have a low tolerance. Although pain is inconvenient and unpleasant, it hints about causes when something is wrong in the body. Pain may be caused due to cramps, headache, bone fractures, stomach pain, arthritis (swelling of one or more joints), muscle strain or overuse, cuts, flu, irritable bowel syndrome (an intestinal disorder causing stomach pain, diarrhoea or constipation) and fibromyalgia (muscle pain with stiffness and tenderness).
FAQs
Tramadol+acetaminophen contains Tramadol and Acetaminophen. Tramadol is an opioid analgesic that works by mimicking the action of endorphins (pain-reducing chemicals) in the brain and spinal cord. Thereby, inhibits the transmission of pain signals from nerves to the brain. Also, it improves the effect of serotonin and noradrenaline (chemical messengers in the brain and spinal cord) and helps in relieving pain. Acetaminophen is an analgesic (relieves pain) and antipyretic (reduces fever) that works by inhibiting the production of certain chemical messengers in the brain known as prostaglandins that are responsible for pain and fever.
Tramadol+acetaminophen may cause dry mouth as a common side effect. It is not necessary for everyone taking Tramadol+acetaminophen to experience this side effect. However, drink plenty of water, suck on sugar candy or chew sugar-free gum to prevent such side effects while taking Tramadol+acetaminophen. If the condition worsens or persist, please consult a doctor.
Tramadol+acetaminophen should be used with caution in patients suffering from fits as it may worsen the condition. Therefore, it is recommended to inform your doctor if you ever had fits before taking Tramadol+acetaminophen.
No, you are not recommended to take Tramadol+acetaminophen with antidepressants (medicines used to treat depression), and antipsychotics (medicines used to treat bipolar disorder and psychosis) as co-administration of these medicines with Tramadol+acetaminophen may increase the risk of fits. However, please consult a doctor before taking Tramadol+acetaminophen with other medicines.
Tramadol+acetaminophen may cause addiction, especially if taken for a prolonged time. Therefore, Tramadol+acetaminophen should be given only for a short duration under strict medical supervision, particularly to patients who are susceptible to drug abuse. Take Tramadol+acetaminophen only as a doctor advised as overuse or misuse of Tramadol+acetaminophen can lead to overdose and cause severe adverse effects.
You are not recommended to take Tramadol+acetaminophen with warfarin as co-administration of these two medicines may increase bleeding risk more easily. However, if you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.
Tramadol+acetaminophen may cause withdrawal symptoms such as difficulty sleeping, anxiety, nervousness, shaking, stomach or bowel disorders, or making you overactive when you stop taking Tramadol+acetaminophen suddenly. Therefore, if you experience any difficulty while taking Tramadol+acetaminophen, do not stop taking suddenly and consult your doctor so that the dose may be reduced gradually to avoid withdrawal symptoms.
