Aprotinin
About
Aprotinin belongs to the group of medicines called anti-fibrinolytic agents used to reduce bleeding during and after heart surgery. It is also used to lower the need for blood transfusion during and after heart surgery.
Aprotinin contains aprotinin that prevents bleeding by inhibiting the activation of coagulants.
Aprotinin will be administered by a healthcare professional; do not self-administer. In some cases, Aprotinin may cause chest pain, stomach upset, fast heartbeat and injection site reactions. You are advised to talk to the doctor if you experience any side effects.
Consult the doctor if you are pregnant or breastfeeding. Aprotinin is not recommended for children below 18 years as the safety and effectiveness have not been established. Keep your doctor informed about your health condition and medications to rule out any unpleasant side effects/interactions.
Uses of Aprotinin
Medicinal Benefits
Aprotinin contains aprotinin that belongs to the group of medicines called anti-fibrinolytic agents used to reduce bleeding during and after heart surgery. It also lowers the need for blood transfusion during and after heart surgery. Aprotinin inhibits the activation of coagulants. Thereby, Aprotinin prevents bleeding.
Directions for Use
Storage
Side Effects of Aprotinin
- Chest pain
- Fast heartbeat
- Stomach upset
- Pain and irritation at the site of administration
In-Depth Precautions and Warning
Drug Warnings
Do not use Aprotinin if you are allergic to any of its components or if a positive aprotinin-specific IgG antibody test is available, indicating an increased risk of an allergic reaction to aprotinin. Inform the doctor if you have kidney problems or have/suspect you have received aprotinin or aprotinin-containing fibrin sealants in the last 12 months. Consult the doctor if you are pregnant or breastfeeding. Let the doctor know if you have any health condition or if you are taking any medications, including herbal products or vitamin/mineral supplements.
Drug Interactions
Drug-Drug Interactions: Inform the doctor if you take medicines used to dissolve blood clots (streptokinase, urokinase, alteplase) or antibiotics (aminoglycosides).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform the doctor if you have kidney problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorIt is not known if Aprotinin interacts with alcohol. Please consult your doctor.
Pregnancy
cautionIf you are pregnant, inform your doctor before receiving Aprotinin. The doctor will prescribe the medicine only if the benefits outweigh the risks.
Breast Feeding
cautionIf you are a nursing mother, inform your doctor before receiving Aprotinin. The doctor will prescribe the medicine only if the benefits outweigh the risks.
Driving
not applicable-
Liver
consult your doctorIf you have a history of liver disease, inform your doctor before receiving Aprotinin.
Kidney
cautionIf you have a history of kidney disease, inform your doctor before receiving Aprotinin. It should be used only in patients with kidney problems if the doctor/surgeon thinks the benefits outweigh the risks.
Children
unsafeAprotinin is not recommended for children below 18 years as the safety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
- Eat a diet rich in whole grains, vegetables, and fruits.
- Cut down on saturated fats, added sugars and salts.
- Manage stress with meditation and yoga.
- Avoid junk food and fast food.
- Follow a low-fat, low-cholesterol, high-fiber diet.
Special Advise
Aprotinin may affect certain lab tests. If you are undergoing any lab tests, inform the doctor that you are on treatment with Aprotinin.
Patients Concern
Disease/Condition Glossary
Perioperative blood management: It is a process to stop or prevent bleeding during surgery and avoid or minimise blood transfusion.
FAQs
Aprotinin works by inhibiting the activation of coagulants. Thereby, Aprotinin prevents bleeding.
Aprotinin is prescribed when the doctor has decided that you will benefit from the treatment because you are at an increased risk of major blood loss as you will undergo a heart bypass operation using the heart-lung machine (circulation outside the body). Your doctor will prescribe Aprotinin only after careful consideration of the benefits and risks.
Aprotinin may raise the risk of kidney problems, and there may be a need for dialysis after surgery. This risk might be higher in patients with existing kidney problems or in people taking medicines that harm the kidneys, such as gentamicin. Therefore, inform the doctor if you have kidney problems.
