Duloxetine+mecobalamin
About
Duloxetine+mecobalamin is a combination medicine used for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation.
Duloxetine+mecobalamin is a combination of two medicines: Duloxetine (mood stabilizer), and Mecobalamin (vitamin B12). Duloxetine is a serotonin-noradrenaline reuptake inhibitor (SNRI). It works by enhancing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain. This Duloxetine+mecobalamin action balances out negative emotions and improves mood, sleep, and makes a person live a better life. Mecobalamin is a Vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a myelin substance. Together, Duloxetine+mecobalamin helps provide relief from neuropathic pain caused due to nerve damage and other neurological disorders.
Take Duloxetine+mecobalamin as prescribed. You are advised to take Duloxetine+mecobalamin for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience nausea, constipation, headache, drowsiness, dry mouth, insomnia (difficulty in sleeping), erectile dysfunction, and low sexual desire. Most of these side effects of Duloxetine+mecobalamin do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
To treat your condition effectually, continue taking Duloxetine+mecobalamin for as long as your doctor has prescribed. Please do not stop taking Duloxetine+mecobalamin without consulting your doctor as it could cause withdrawal symptoms. Keep your doctor informed about your health condition and medicines to rule out any side effects. Duloxetine+mecobalamin should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Duloxetine+mecobalamin as it could lead to increased dizziness and sleepiness. Do not take Duloxetine+mecobalamin if you are pregnant or breastfeeding unless prescribed by the doctor. Inform your doctor immediately, if you experience suicidal thoughts after taking Duloxetine+mecobalamin. Also, seek medical help immediately if you have serotonin syndrome symptoms, such as agitation, hallucinations, fever, shivering, muscle stiffness, twitching, nausea, vomiting, or diarrhoea.
Uses of Duloxetine+mecobalamin
Medicinal Benefits
Duloxetine+mecobalamin is used to treat neuropathic pain in adults. Duloxetine+mecobalamin is a combination of two medicines: Duloxetine (mood stabilizer), Mecobalamin (vitamin B12). Gabapentin treats seizures by balancing a chemical messenger in the brain called a neurotransmitter, thereby decreasing its abnormal excitement in the brain. Mecobalamin is a Vitamin B12 that helps rejuvenate and protect damaged nerve cells by producing a myelin substance. Together, Duloxetine+mecobalamin helps provide relief from neuropathic pain caused due to nerve damage and other neurological disorders.
Directions for Use
Storage
Side Effects of Duloxetine+mecobalamin
- Nausea
- Constipation
- Headache
- Insomnia (difficulty in sleeping)
- Erectile dysfunction
- Low sexual desire
- Dry mouth
- Drowsiness
In-Depth Precautions and Warning
Drug Warnings
Do not take Duloxetine+mecobalamin if you are allergic to any of its contents. Inform your doctor before taking Duloxetine+mecobalamin if you have liver or kidney disease, slow digestion, bleeding problems, narrow-angle glaucoma, bipolar disorder. Avoid taking Duloxetine+mecobalamin within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, methylene blue injection, linezolid, phenelzine, selegiline, or tranylcypromine. Please do not stop taking Duloxetine+mecobalamin without consulting your doctor as it could cause withdrawal symptoms. Duloxetine+mecobalamin causes drowsiness and dizziness, so drive only if you are alert. Duloxetine+mecobalamin should not be given to children as safety and effectiveness have not been established. Consult your doctor immediately if you experience suicidal tendencies. Do not take Duloxetine+mecobalamin if you are pregnant or breastfeeding unless prescribed by the doctor. Do not get up too fast from a sitting or lying position. Please do not drink alcohol as it may increase your risk of liver damage.
Drug Interactions
Drug-Drug Interactions: Duloxetine+mecobalamin may have interaction aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam.
Drug-Food Interactions: Avoid alcohol consumption while taking Duloxetine+mecobalamin as it might cause increased dizziness and sleepiness or may increase your risk of liver damage.
Drug-Disease Interactions: Duloxetine+mecobalamin may interact with disease conditions such as liver or kidney disease, seizures, bipolar disorder (manic depression), drug addiction or suicidal thoughts, narrow-angle glaucoma.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Duloxetine+mecobalamin as it may increase dizziness and sleepiness.
Pregnancy
cautionAvoid taking Duloxetine+mecobalamin if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionConsult your doctor before taking Duloxetine+mecobalamin; your doctor will decide whether Duloxetine+mecobalamin can be taken by breastfeeding mothers or not.
Driving
unsafeDuloxetine+mecobalamin causes drowsiness, sleepiness. Do not drive or operate machinery unless you are alert.
Liver
cautionDose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeDuloxetine+mecobalamin should not be given to children and adolescents aged less than 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Include food rich in vitamins B and D in your diet to improve nerve health and prevent nerve pain.
- Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
- Exercising regularly helps in improving overall health and combating pain.
- Rest well, and get plenty of sleep.
- Try taking a warm bath as it can be soothing. It helps in increasing blood circulation, thereby decreasing numbness and pain.
- Avoid smoking and alcohol consumption.
- Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
- Physical relaxation and massages can help provide symptomatic relief.
- Learn about techniques for sitting, stretching, moving, and standing from a physical or occupational therapist. These can help prevent pain.
- Acupuncture can be helpful by stimulating pressure points.
- Using essential oils for massages can help increase circulation and boosts healing.
Special Advise
- Close monitoring for suicidal thoughts/behavior is required for people using Duloxetine+mecobalamin.
- Using Duloxetine+mecobalamin in children can cause emotional changes, aggressive behavior, concentration problems, restlessness, school performance changes, and hyperactivity.
Patients Concern
Disease/Condition Glossary
Neuropathic pain: It is a nervous system disorder caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
FAQs
Yes, some young people who have taken Duloxetine+mecobalamin have experienced suicidal thoughts, so people of that age group should be monitored closely while on Duloxetine+mecobalamin. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.
Yes, Duloxetine+mecobalamin may rarely cause weight gain, but is not experienced by everyone. Follow the regular diet and exercise to maintain a healthy weight.
Dry mouth could be a side-effect of Duloxetine+mecobalamin. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not discontinue Duloxetine+mecobalamin without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually continue taking Duloxetine+mecobalamin for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Duloxetine+mecobalamin; your doctor will reduce the dose gradually.
Duloxetine+mecobalamin is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.
Duloxetine+mecobalamin may cause sexual disturbances such as decreased sex drive and problems with erection. Consult your doctor if you have any concerns regarding this.
