Isosorbide Mononitrate+aspirin
About
Isosorbide Mononitrate+aspirin belongs to a class of antianginals, which is used to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently.
Isosorbide Mononitrate+aspirin is a combination of medication containing Isosorbide Mononitrate and aspirin. Isosorbide Mononitrate is a powerful vasodilator (widens blood vessels). It works by forming the free radical nitric oxide (NO) inside our body which leads to relaxation of the muscles of blood vessels, especially of the heart leading to proper blood flow towards the heart muscle, which has been working under immense pressure due to decreased blood flow to it. Aspirin has an antithrombotic action that interferes with platelet functioning and does not let them stick together, thus helping to prevent or reduce blood clots. Altogether, Isosorbide Mononitrate+aspirin is helpful in treating and preventing episodes of angina.
Take Isosorbide Mononitrate+aspirin as prescribed by the doctor. The dose of Isosorbide Mononitrate+aspirin can vary depending upon your condition and the severity of the condition. Also, it is recommended to complete the course of medicine even if you feel better. The common side effects of Isosorbide Mononitrate+aspirin include increased bleeding tendency, stomach pain, diarrhoea, headache, indigestion, dizziness, and itching. In case of any discomfort, speak with a doctor.
Take Isosorbide Mononitrate+aspirin only if the doctor prescribes you. Never encourage self-medication or suggest your medicine to someone else. You should not take Isosorbide Mononitrate+aspirin if you have severe anemia, low blood volume, gout, severe kidney or liver problems, blood clotting disorder, or ulcer in the stomach or intestine. Also, do not take Isosorbide Mononitrate+aspirin if you are taking medicines like methotrexate(for cancer) and medicines for erectile dysfunction such as sildenafil, vardenafil, and tadalafil. Check with your doctor if you're pregnant, currently breastfeeding, or taking any other prescribed or non-prescribed medicines. Also, do not stop Isosorbide Mononitrate+aspirin abruptly, as it may lead to severe side effects. Avoid alcohol consumption as it might lead to very low blood pressure.
Uses of Isosorbide Mononitrate+aspirin
Medicinal Benefits
Isosorbide Mononitrate+aspirin belongs to a class of medicines called antianginal. It is a combination of medication containing Isosorbide Mononitrate and aspirin. Isosorbide Mononitrate is a powerful vasodilator that operates by relaxing the blood vessels of the heart, reducing the stress on the heart and making it easier to pump blood. Angina usually feels like tight chest pain, neck or arm area. The pain originates from the heart muscle and is a sign that part of it is not getting enough oxygen for the amount of work it is doing. Aspirin works as an antithrombotic action that affects platelet functioning and does not let them stick together, thus helping to prevent or reduce blood clots. As a combination medication, Isosorbide Mononitrate+aspirin reduces the risk of further heart attack or stokes or of dying from one of these atherothrombotic events.
Directions for Use
Storage
Side Effects of Isosorbide Mononitrate+aspirin
- Stomach pain
- Diarrhea
- Headache
- Dizziness
- Itching
- Flushing of skin
- Increased bleeding tendency
In-Depth Precautions and Warning
Drug Warnings
Inform to your doctor or pharmacist before taking Isosorbide Mononitrate+aspirin if you have underactive thyroid gland, severe liver or kidney problems, serious damage to heart, glaucoma, gout, high blood pressure, or if you are a women with heavy menstrual periods. Seek medical help immediately if you experience unusual bleeding symptoms, fainting or collapse, or allergic symptoms. Check with your doctor if you're pregnant, currently breastfeeding or taking any other prescribed or non-prescribed medicines. Also, do not stop Isosorbide Mononitrate+aspirin abruptly as it may lead to severe side-effects. Avoid alcohol consumption as it might lead to very low blood pressure. Drink plenty of liquids while taking this medicine as advised by your doctor.
Drug Interactions
Drug-Drug Interaction: Isosorbide Mononitrate+aspirin may interact with medicines used to treat male erection dysfunction (Sildenafil, tadalafil, and vardenafil), anticancer drug (methotrexate), medicine for psoriasis (ciclosporin), drug used for termination of pregnancy (mifepristone), antiasthma drug (zafirlukast), Antacids, anticonvulsant (sodium valproate), vasodilator (nitroglycerin), blood pressure medications including calcium channel blockers (nifedipine), blood thinners (warfarin).
Drug-Food Interaction: Avoid taking Isosorbide Mononitrate+aspirin alongside alcohol.
Drug-Disease Interaction: Inform your doctor if you have stomach or intestinal bleeding, kidney failure, high blood pressure, liver disease, heart disease.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol should not be taken while using Isosorbide Mononitrate+aspirin.
Pregnancy
cautionIf you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Breast Feeding
cautionIf you are a breast-feeding mother, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving
unsafeIsosorbide Mononitrate+aspirin may give you headache, blurred vision or make you feel dizzy or tired make sure you are not affected before you drive or operate machinery.
Liver
cautionIsosorbide Mononitrate+aspirin should be used with caution in patients with liver diseases. Therefore, the doctor may adjust the dose while using it in patients with liver diseases.
Kidney
cautionIsosorbide Mononitrate+aspirin should be used with caution in patients with kidney diseases. Therefore, the doctor may adjust the dose while using it in patients with kidney diseases.
Children
unsafeNot to be given in children unless prescribed by a doctor.
Habit Forming
Diet & Lifestyle Advise
- Adopting a heart-healthy lifestyle will help you keep your cholesterol and blood pressure down, keep your arteries clear and avoid angina.
- Limit or completely avoid the intake of alcohol as it may worsen the side effects, including dizziness.
- According to BMI, manage weight and lose extra pounds. Excess body weight puts extra strain on the heart.
- Include more vegetables and fruits in your diet as these foods are a good source of vitamins and minerals and improve heart health.
- Quit smoking, as smoking is a significant cause of heart problems. Any smoking will gradually worsen the condition, so stopping smoking is the only step a person can take to improve their health.
- Being physically active will prevent the medical condition from getting worse.
- Exercise, walking, and running help to control cholesterol levels and blood pressure, improving heart health.
Special Advise
- Avoid vigorous physical activity that may aggravate anginal attack.
- Avoid smoking.
- A patient should avoid places where airflow is restricted.
Patients Concern
Disease/Condition Glossary
Angina: Angina or chest pain is the most common indication of heart disease caused due to decreased blood flow to heart muscles. The heart is dependent on oxygen for its functioning and pumping of blood, yet sometimes due to various genetic and environmental reasons, the blood vessels supplying blood to the heart narrow unexpectedly, causing decreased blood flow to the heart. This abrupt decrease in blood flow leads to increased stress on the heart to pump blood towards different organs, causing an event of acute chest pain that starts from the arm along the jaw and finally involves the chest. Angina pectoris is of 3 types:
1) Stable Angina: It is the most common type in which blood flow to the heart is low compared to what it needs to function, caused by increased physical activity.
2) Unstable Angina: It is the most lethal type in which blood supply to the heart decreases abruptly due to blockage of an artery by a clot etc.
3) Variant Angina: It occurs at rest due to spasmodic narrowing of the artery.
FAQs
If you miss a dose of Isosorbide Mononitrate+aspirin, take the missed dose as soon as you remember it. However, if it’s almost time for the next dose, do not take a double dose to make up for a missed one.
It can induce headache, spinning sensation, blurry vision, fainting or passing out if you take more than the prescribed dose of Isosorbide Mononitrate+aspirin. Seek emergency treatment and seek urgent consultation with your doctor if you are taking more than the prescribed dosage of this drug.
Isosorbide Mononitrate+aspirin should not be taken before doing any physical workout to prevent angina pain. A person should consult with the doctor to know the right time of taking Isosorbide Mononitrate+aspirin.
Yes, Isosorbide Mononitrate+aspirin can cause a headache. Please increase fluid intake as it is known to decrease headache when taking Isosorbide Mononitrate+aspirin. If the problem persists, consult your doctor and do as advised.
Isosorbide Mononitrate+aspirin is not advised in patients with severe anaemia, and one should tell their doctor if they have this condition
A person who is already taking phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, should not consume Isosorbide Mononitrate+aspirin as it may cause serious side effects in the body.
It is suggested to take Isosorbide Mononitrate+aspirin in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
A person should not take Isosorbide Mononitrate+aspirin with your erectile dysfunction medication as it might trigger the blood pressure-lowering effect of Isosorbide Mononitrate+aspirin. Consult your doctor for further advice.
A person should not stop taking Isosorbide Mononitrate+aspirin without talking to your doctor. If they suddenly stop taking Isosorbide Mononitrate+aspirin, then they may experience confusion, fever, mental state changes, or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.
