Prulifloxacin

Prulifloxacin should be avoided if you are pregnant or planning to become pregnant and breastfeeding unless your doctor prescribed it. Taking Prulifloxacin may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney or liver disease, heart or lung transplant, seizures (fits), epilepsy or if you participate in regular physical activity. Taking Prulifloxacin may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Patients with epilepsy and irregular heartbeat (especially a condition known as QT prolongation) should tell their doctor before taking Prulifloxacin. Dairy products should be avoided along with Prulifloxacin. And also, exposure to sunlight should be avoided while taking Prulifloxacin as it may cause increased phototoxicity or photosensitivity.

Drug-Drug Interaction: Prulifloxacin is known to interact with blood thinner (warfarin) antacids containing (calcium, magnesium, aluminium), a medicine used to treat asthma (theophylline), antiulcer (cimetidine) antigout (probenecid), pain killers (ibuprofen, naproxen, aspirin, diclofenac, celecoxib), antidiabetic medicines (chlorpropamide, glimepiride, glipizide, glyburide, tolazamide, tolbutamide), medicine used to treat high blood pressure (nicardipine).

Drug-Food Interaction:  Prulifloxacin interacts with alcohol and antacids containing aluminum and magnesium. Also, it is known to interact with dairy products.

Drug-Disease Interaction: Prulifloxacin is known to interact in patients with kidney or liver disease, heart, or lung transplant, seizures, epilepsy, hypertension (high blood pressure), diabetes, myasthenia gravis (a muscle disorder),  low level of potassium or magnesium in the blood.

• Probiotics should be taken after taking the full course of Prulifloxacin to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
• Include more fiber-enriched food in your diet, as it can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking Prulifloxacin.
• Avoid alcohol, soda, coffee, tea, and artificial sweeteners as they may cause bladder irritation. 
• Drink plenty of water to flush out the bacteria.
• Avoid spicy foods and citrus fruits (lemons, oranges, grapefruits) as they may irritate the bladder. 
• Eat foods antioxidant-rich foods such as blueberries, cranberries, tomatoes, spinach, broccoli, and plain greek yogurt.

• During treatment and after 48 hours of discontinuation of treatment with Prulifloxacin, limit exposure to heavy sunlight or artificial UV rays (e.g. sunlight).
• Please consult a doctor if the infection persists or worsens after 1 week of using Prulifloxacin.
• Monitor liver function test (LFT), renal function test, white blood cell count, blood glucose level in diabetic patients as Prulifloxacin may cause harmful interactions in these patients.
• Prulifloxacin can cause dehydration, so please increase the intake of fluids.
• Prulifloxacin is known to cause tendon rupture, so be cautious while taking Prulifloxacin if you have a tendon rupture history.
• Prulifloxacin may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. So, do not have any immunizations/vaccinations while using this medication unless your doctor tells you.