Ramipril+atorvastatin+aspirin
About
Ramipril+atorvastatin+aspirin is a combination drug of blood thinners, cholesterol-lowering agents and blood pressure-lowering agents primarily used to prevent heart attack and stroke. Besides this, it also lowers the raised level of bad cholesterol (especially for those at high risk of heart disease). A heart attack generally refers to a blocked flow of blood to the heart due to the blockage of arteries. The blockage is most often a build-up of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).
Ramipril+atorvastatin+aspirin is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin is a cholesterol-lowering medication that blocks the enzyme required to make fat in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). Aspirin is blood thinners or antiplatelet (anticoagulant) that collectively prevent clots in the blood vessels. Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lowers increased blood pressure by blocking a naturally occurring substance known as angiotensin II that tightens your blood vessels, thereby relaxing blood vessels in the body and reducing overload on the heart to pump more blood. Together Ramipril+atorvastatin+aspirinminimisess the risk of heart attack, stroke, and heart-related chest pain (angina).
Depending upon your medical condition, you are advised to take Ramipril+atorvastatin+aspirin for as long as your doctor has prescribed it for you. The most common side effects of Ramipril+atorvastatin+aspirin are increased bleeding tendency, constipation, headache, muscle pain, weakness, headaches, decreased blood pressure, dizziness, muscle pain, increased blood glucose level, and cough in some cases. Most of these side effects of Ramipril+atorvastatin+aspirin do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking this medicine of your own. Stopping Ramipril+atorvastatin+aspirin abruptly may worsen your condition and increase your risk of a future heart attack. Let your doctor know if you are sensitive to atorvastatin, or aspirin, have any active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), muscle problems (myopathy, rhabdomyolysis), are pregnant or planning to become pregnant or breastfeeding. Atorvastatin, present in Ramipril+atorvastatin+aspirin, is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to pregnant women. Disclose to your doctor that you are taking Ramipril+atorvastatin+aspirin if you are going to have any surgery.
Uses of Ramipril+atorvastatin+aspirin
Medicinal Benefits
Ramipril+atorvastatin+aspirin is a combination drug of a blood-thinning agent (aspirin), cholesterol-lowering agent (atorvastatin) and blood pressure-lowering agent (ramipril) primarily taken to prevent heart attack and stroke in people with heart problems. It also lowers the raised level of bad cholesterol (especially for those at high risk of heart disease). Additionally, it is also given to patients who had a recent heart bypass surgery to control cholesterol levels and prevent blood clots. Ramipril+atorvastatin+aspirin is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin is a lipid-lowering medication that blocks the enzyme required to make cholesterol in the body. It reduces the bad cholesterol (also known as low-density lipoproteins or LDL) and triglycerides (TG) and increases the levels of good cholesterol (also known as high-density lipoproteins or HDL). Aspirin is blood thinners or antiplatelet (anticoagulant) that collectively prevent clots in the blood vessels. Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lower increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and helps lower high blood pressure. Together Ramipril+atorvastatin+aspirin reduces the risk of heart attack, stroke, and heart-related chest pain (angina).
Directions for Use
Storage
Side Effects of Ramipril+atorvastatin+aspirin
- Bleeding tendency
- Constipation
- Headache
- Muscle pain
- Weakness
- Headaches
- Decreased blood pressure
- Dizziness
- Muscle pain
- An increased blood glucose level
- Cough in some cases
In-Depth Precautions and Warning
Drug Warnings
Inform your doctor if you are highly sensitive to atorvastatin, ramipril or aspirin, have any active liver disease, have active bleeding issues (like a peptic ulcer or brain haemorrhage), are pregnant or planning to become pregnant, or breastfeeding. The patient should inform the doctor they are taking Ramipril+atorvastatin+aspirin before any surgery or any new medicine is taken. Atorvastatin, present in Ramipril+atorvastatin+aspirin, is a pregnancy category X drug, so it is contraindicated in pregnant women. As it may cause harm to the fetus if administered to a pregnant woman. Co-administration with anticoagulants like warfarin may cause gastric bleeding and other bleeding problems. So, if you are using any blood-thinning agents, let your doctor know about this. Ramipril+atorvastatin+aspirin contains atorvastatin which can cause muscle problems like myopathy and rhabdomyolysis. So, any signs of muscle pain, tenderness, or weakness, during the initial months of the treatment should be closely monitored. Patients with active liver disease should use Ramipril+atorvastatin+aspirin with caution. The safety and effectiveness of Ramipril+atorvastatin+aspirin have not been established, so its use should be avoided in pediatric patients or children less than 12 years of age. Discontinuation of Ramipril+atorvastatin+aspirin may lead to cardiovascular events like heart attack, stroke, and angina (heart-related chest pain). Hence, you should consult a doctor before stopping the dose of Ramipril+atorvastatin+aspirin.
Drug Interactions
Drug-Drug Interactions: Ramipril+atorvastatin+aspirin interacts with Ramipril+atorvastatin+aspirin, so it should be used with caution with an antibiotic (clarithromycin), anti-HIV drugs (ritonavir, lopinavir, darunavir, atazanavir, indinavir) and antifungal (itraconazole), blood thinners (warfarin, heparin), anti-arthritis drug (colchicine), heart-related medicine (digoxin), and immune system affecting drug (cyclosporine).
Drug-Food Interactions: Alcoholic beverages and grapefruit or its juice intake should be avoided with Ramipril+atorvastatin+aspirin as it may interact with Ramipril+atorvastatin+aspirin to produce unpleasant side effects.
Drug-Disease Interactions: Ramipril+atorvastatin+aspirin should not be given to the patients with active liver disease, active bleeding issues (like peptic ulcer, brain haemorrhage), muscle problems or musculoskeletal problems (myopathy, rhabdomyolysis), asthma, purpura (blood leakage under the skin), patients with nil urine output (anuria), cardiogenic shock (when the heart fails to pump required blood to the body), low blood pressure (hypotension), coronary heart disease, heart failure, high serum potassium (hyperkalemia), patients with nil urine output (anuria).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionRamipril+atorvastatin+aspirin should not be taken until prescribed if you are taking alcohol. Keep your doctor informed if you drink alcohol. Drinking alcohol with Ramipril+atorvastatin+aspirin may potentiate gastrically or stomach bleeding and ulcer symptoms. So, try to avoid or limit the consumption of alcoholic beverages while using Ramipril+atorvastatin+aspirin.
Pregnancy
unsafeRamipril+atorvastatin+aspirin contains Atorvastatin, which is a pregnancy category X medicine. So, it is not recommended for pregnant mothers or those who are planning to get pregnant. In an extreme case, your doctor will decide whether Ramipril+atorvastatin+aspirin can be given or not.
Breast Feeding
cautionTake Ramipril+atorvastatin+aspirin only when prescribed, as it is known to pass on in a limited quantity via breast milk to the child. Contact your doctor before using the Ramipril+atorvastatin+aspirin.
Driving
cautionDrive with caution as Ramipril+atorvastatin+aspirin can cause dizziness and may affect your driving ability.
Liver
cautionRamipril+atorvastatin+aspirin to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor will adjust the dose.
Kidney
cautionRamipril+atorvastatin+aspirin to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor will adjust the dose.
Children
cautionRamipril+atorvastatin+aspirin is not recommended for children below the age of 12 years. The safety and effectiveness of Ramipril+atorvastatin+aspirin have not been established in children due to limited testing of this drug on children by competent authorities worldwide.
Habit Forming
Diet & Lifestyle Advise
- Eat a healthy diet rich in soluble fibre like beans, legumes, whole grains, flax, apples, and citrus fruits.
- Try to replace most of your saturated fats with unsaturated fats that can reduce total cholesterol and LDL cholesterol quickly. Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so it’s beneficial to eat them regularly.
- Try to adopt a Mediterranean-style diet rich in olive oil, fruits, vegetables, nuts, whole grains, and fish, low in red meat and most dairy.
- Try to give priority to more fruits and veggies in your daily meal as these contain antioxidants that help to lower LDL - low-density lipoprotein (bad cholesterol)
- Minimize the intake of added sugar. The American Heart Association (ADA) recommends one should not eat more than 100 calories (25 grams) of added sugar for women and children and no more than 150 calories (37.5 grams) for men every day.
- American Heart Association recommends sodium chloride intake (table salt) should not exceed more than 2,300 mg per day as part of a healthy eating pattern.
- As a precautionary measure, do not consume alcohol and quit smoking.
Special Advise
- Please monitor your blood sugar (H1b1AC) level regularly.
Patients Concern
Disease/Condition Glossary
Heart attack: A heart attack generally refers to a blocked flow of blood to the heart due to the blockage of arteries. The blockage is most often a build-up of fat, cholesterol, and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).
Stroke: Stroke occurs when the blood and oxygen supply to the brain is limited or stopped. When the brain does not receive sufficient oxygen and nutrients, it starts dying within a few minutes. If not treated early, it is a life-threatening condition that can lead to brain damage, coma, and even death.
FAQs
Ramipril+atorvastatin+aspirin is composed of three medicines: Atorvastatin, Ramipril, and Aspirin. Atorvastatin lowers raised fat/cholesterol; aspirin prevents blood clots in the arteries, and ramipril lowers increased blood pressure. Thus, together Ramipril+atorvastatin+aspirin reduces the risk of heart attack, stroke, and heart-related chest pain (angina).
Usually, Ramipril+atorvastatin+aspirin is prescribed for long-term treatment ranging from weeks to months for treating heart-related conditions and disorders. However, taking it on your own for years without a doctor's consent can be fatal. Hence, only take it as long as your doctor prescribes it.
Ramipril+atorvastatin+aspirin can raise your blood sugar, so if you already have type 2 diabetes, please consult your doctor. The doctor will weigh the benefits and potential risks before prescribing them.
Ramipril+atorvastatin+aspirin contains aspirin, which can increase your bleeding risk and increase the blood clot time. Please consult your doctor if the Ramipril+atorvastatin+aspirin needs to be stopped before surgery. The doctor might ask you to stop taking Ramipril+atorvastatin+aspirin a few days before surgery to avoid the increased risk of bleeding during the procedure.
If you forget to take Ramipril+atorvastatin+aspirin at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
Yes, taking Ramipril+atorvastatin+aspirin can increase the risk of bleeding as it contains aspirin, which is a blood thinner. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid bleeding.
Musculoskeletal pain, abdomen pain, cough, dizziness, low blood pressure, stomach ulcer/bleeding, and bleeding problems are the common side effects of Ramipril+atorvastatin+aspirin, which can be reported in some patients.
