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Reteplase

About

Reteplase is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.
 
Reteplase contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.
 
In some cases, Reteplase may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of Reteplase in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Reteplase

ST-elevation myocardial infarction (STEMI)

Medicinal Benefits

Reteplase is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. Reteplase contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).

Directions for Use

Reteplase will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Reteplase

  • Bleeding
  • Bruising at the injection site
  • Vomiting
  • Nausea

In-Depth Precautions and Warning

Drug Warnings

Reteplase should not be used if you are allergic to any of the components in Reteplase, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. Reteplase may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of Reteplase in children have not been established.

Drug Interactions

Drug-Drug Interactions: Inform your doctor if you are taking anti-coagulants (heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, vitamin K antagonists).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have/had cancer, stroke, high blood pressure, active ulcer in the stomach or intestine, portal hypertension, inflammation of the pancreas, bleeding behind or in the eye, or severe liver or kidney problems.

Drug-Drug Interactions Checker List:

  • HEPARIN
  • ENOXAPARIN
  • WARFARIN
  • PHENINDIONE
  • ASPIRIN
  • DIPYRIDAMOLE
  • TICLOPIDINE
  • CLOPIDOGREL
  • Safety Advice

    • Safety Warning

      Alcohol

      consult your doctor

      Limited information is available. Please consult your doctor.

    • Safety Warning

      Pregnancy

      caution

      Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.

    • Safety Warning

      Breast Feeding

      caution

      Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering Reteplase to a nursing mother.

    • Safety Warning

      Driving

      consult your doctor

      Limited information is available. Please consult your doctor.

    • Safety Warning

      Liver

      caution

      The potential risks with the therapy of Reteplase may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

    • Safety Warning

      Kidney

      caution

      The potential risks of Reteplase therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.

    • Safety Warning

      Children

      caution

      The efficacy and safety of Reteplase in children have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Include vegetables, fruits and whole grains in your diet.
    • Stop smoking.
    • Be physically active every day.
    • Aim for a healthy weight.
    • Limit the consumption of alcohol.
    • Manage stress with meditation.

    Patients Concern

    Disease/Condition Glossary

    ST-elevation myocardial infarction (STEMI): It is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries. Signs and symptoms include dizziness or light-headedness, chest pain or discomfort, shortness of breath, nausea or vomiting, palpitations, anxiety, or sweatiness unexplained by ambient temperature.

    FAQs

    Reteplase works by dissolving the blood clot that is blocking the heart's blood vessels.

    Reteplase may increase the risk of bleeding. The sites of bleeding could be internal or external. Talk to your doctor if you have any concerns.

    Heparin and Reteplase are incompatible. Reteplase should not be administered through an intravenous line containing heparin. Please consult your doctor if you have any concerns.

    Available Medicines for

    Reteplase

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