Isosorbide Dinitrate+hydralazine
About
Isosorbide Dinitrate+hydralazine belongs to a group of heart-related medicines called 'vasodilators used to treat heart failure. Heart failure occurs when the heart muscle does not pump blood normally, including shortness of breath, swollen legs, fatigue and increased heartbeat. In this condition, the heart becomes too weak and cannot pump enough blood and oxygen to the organs and tissues of our body.
Isosorbide Dinitrate+hydralazine is a fixed-dose combination composed of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate is a group of drugs known as nitrates that relax the heart's muscles and widen the heart's veins and arteries for easy flow of blood to every part of our body. It is used to treat angina (chest pain) and other heart-related diseases due to a shortage of oxygen and blood. Hydralazine belongs to a group of drugs known as vasodilators which help lowers raised blood pressure by relaxing and widening the heart's muscles.
Isosorbide Dinitrate+hydralazine is available in the form of oral tablets. Take Isosorbide Dinitrate+hydralazine as your doctor has prescribed it. Doses of the Isosorbide Dinitrate+hydralazine will decide by your doctor, but generally, start with low doses and increase the amount. In some cases, Isosorbide Dinitrate+hydralazine can cause side effects like headache, nausea, dizziness, and lightheadedness (feeling faint). Most of these side effects of Isosorbide Dinitrate+hydralazine do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.
If you are known to be allergic to Isosorbide Dinitrate+hydralazine or any other medicines, please inform your doctor. Before taking Isosorbide Dinitrate+hydralazine, let your doctor know if you have had a heart attack within the last 30 days, low blood pressure, stroke (inadequate blood supply in the brain that causes damage to the brain), or high pressure within the brain. Please do not stop taking Isosorbide Dinitrate+hydralazine on your own, which may lead to the recurrence of symptoms or worsen the condition.
Uses of Isosorbide Dinitrate+hydralazine
Medicinal Benefits
Isosorbide Dinitrate+hydralazine belongs to a group of vasodilators used to treat heart failure. Isosorbide Dinitrate+hydralazine is a fixed-dose combination composed of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate belongs to a group of drugs known as nitrates. Isosorbide dinitrate relaxes the heart's muscles and stretches or enlarges the heart's veins and arteries. It treats angina (chest pain) and other heart-related diseases. Hydralazine belongs to a group of drugs known as vasodilators which help lowers raised blood pressure by relaxing and widening the heart's blood vessels.
Directions for Use
Storage
Side Effects of Isosorbide Dinitrate+hydralazine
- Headache
- Nausea
- Dizziness
- Lightheadedness (feeling faint)
In-Depth Precautions and Warning
Drug Warnings
Do not take Isosorbide Dinitrate+hydralazine if you have low blood pressure because even a low dose of Isosorbide Dinitrate+hydralazine may produce low blood pressure. If you are pregnant or planning any pregnancy, let your doctor know about this before taking Isosorbide Dinitrate+hydralazine as it crosses the placenta and can affect the unborn baby (fetus). Do not drive by using this Isosorbide Dinitrate+hydralazine because it produces dizziness that may cause an accident. You may experience tingling or numbness, so your doctor may prescribe a vitamin B6 supplement (pyridoxine). Hydralazine passes into breast milk, so its use in lactating mothers should be avoided.
Drug Interactions
Drug-Drug Interactions: Care should be exercised when Isosorbide Dinitrate+hydralazine is administered in combination with migraine headache medicines (ergotamine), drugs used to treat erectile dysfunction (inability to get enlarged penis) (sildenafil, tadalafil), pain killers (ibuprofen, naproxen).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Isosorbide Dinitrate+hydralazine may interact with disease conditions, including hypotension (low blood pressure) and erectile dysfunction (inability to get an enlarged penis).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionConsuming alcohol with the Isosorbide Dinitrate+hydralazine is not advisable as it may cause unpleasant side effects, or you may become more sensitive to the effects of alcohol.
Pregnancy
cautionIsosorbide Dinitrate+hydralazine is not recommended during pregnancy. Please discuss with the doctor if you have any concerns.
Breast Feeding
cautionIsosorbide Dinitrate+hydralazine is not recommended during nursing. Please discuss with the doctor if you have any concerns.
Driving
cautionIsosorbide Dinitrate+hydralazine may cause dizziness in some people, so it may affect your ability to drive.
Liver
cautionIsosorbide Dinitrate+hydralazine to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionIsosorbide Dinitrate+hydralazine to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
cautionThe safety and effectiveness of Isosorbide Dinitrate+hydralazine in children have not been established.
Habit Forming
Diet & Lifestyle Advise
- Follow a cholesterol-lowering diet.
- Consume low salt and a low-fat diet.
- Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
- Limit salt and sugar intake.
- Avoid smoking and alcohol consumption.
- Choose healthy fats and cut down on trans fat.
- Include omega-3 fatty acids, fibre-rich food, fruits, and vegetables.
- Get active by doing physical activities such as swimming, brisk walking, or jogging. Take the stairs instead of elevators/lifts.
Special Advise
Patients Concern
Disease/Condition Glossary
Heart failure occurs when the heart's muscle does not properly pump blood to the body parts. Heart failure symptoms include shortness of breath, swollen legs, fatigue (lack of energy or feeling of tiredness), and increased heartbeat. In this condition, the heart becomes too weak and does not pump enough. It is a life-threatening condition and requires immediate hospitalization.
FAQs
Isosorbide Dinitrate+hydralazine can sometimes cause headaches, generally at the start of the treatment. As the treatment continues, your headache may become less severe and frequent. If the headache continues, inform your doctor.
Yes, the use of Isosorbide Dinitrate+hydralazine can make you feel dizzy. This may often occur when you suddenly rise from a sitting or lying position. To lower the chance of feeling dizzy (faint) or passing out, rise slowly if you have been lying down or sitting.
No, keep using the Isosorbide Dinitrate+hydralazine as advised by your doctor, even if you feel well. Stopping the Isosorbide Dinitrate+hydralazine suddenly may lead to serious complications of heart failure.
Isosorbide Dinitrate+hydralazine is a fixed-dose combination composed of two medicines: Isosorbide dinitrate and Hydralazine. Isosorbide dinitrate is a group of drugs known as nitrates that relax the heart's muscles and widen the heart's veins and arteries for easy flow of blood to every part of our body. It is used to treat angina (chest pain) and other heart-related diseases due to a shortage of oxygen and blood. Hydralazine belongs to a group of drugs known as vasodilators which help lowers raised blood pressure by relaxing and widening the heart's muscles.
Keep this medicine tightly closed in the container or the pack it came in. Store it according to the instructions mentioned on the pack or label. Dispose of unused medicine. Make sure pets, children, and other people do not consume it.
