Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate
About
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses.
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate contains Dolutegravir (integrase inhibitor), Lamivudine (nucleoside reverse transcriptase inhibitor), and Tenofovir disoproxil fumarate (nucleotide reverse transcriptase inhibitor). Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate helps in treating HIV infection.
You are advised to take Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as fatigue, diarrhoea, headache, pain, rash, depression, fever, cough, and insomnia. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Practise safe sex and other necessary precautions as Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate. Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate may cause dizziness, so drive with caution. Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate is not recommended for children weighing below 35 kg. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.
Uses of Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate
Medicinal Benefits
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate is a combination of three drugs, namely: Dolutegravir, Lamivudine and Tenofovir disoproxil fumarate. Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate belongs to a group of antiretroviral medicines indicated for the treatment of HIV-1 infection in adults and children weighing at least 35kgs. Dolutegravir is an integrase inhibitor that increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine is a nucleoside reverse transcriptase inhibitor, and Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor. They work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate helps in treating HIV infection.
Directions for Use
Storage
Side Effects of Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate
- Fatigue
- Diarrhoea
- Headache
- Pain
- Rash
- Depression
- Fever
- Cough
- Insomnia
In-Depth Precautions and Warning
Drug Warnings
Do not take Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate if you are allergic to any of its components. Inform your doctor if you have a history of hepatitis B or C infection, bone problems, pancreas disorder, kidney/liver problems, or if you are taking dofetilide (anti-arrhythmic agent). Practise safe sex and other necessary precautions as Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate does not prevent the spread of HIV infection. Consult your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate. Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate may cause dizziness, so drive with caution. Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate is not recommended for children weighing below 35 kg. Talk to your doctor immediately if you notice any signs or symptoms of infection or inflammation.
Drug Interactions
Drug-Drug Interactions: Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate may interact with an anti-arrhythmic agent (dofetilide)
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have hepatitis B, pancreatitis, bone problems, kidney or liver problems.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is not known whether Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate interacts with alcohol. Please consult your doctor.
Pregnancy
unsafeDolutegravir+lamivudine+tenofovir Disoproxil Fumarate might cause embryo-fetal toxicity when taken at the time of conception and during early pregnancy. Please consult your doctor if you have any concerns regarding this.
Breast Feeding
unsafeAvoid breastfeeding while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate. Consult your doctor if you have any concerns regarding this.
Driving
cautionDolutegravir+lamivudine+tenofovir Disoproxil Fumarate may cause dizziness. So, drive or operating machinery only if you are alert.
Liver
cautionDose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
cautionDolutegravir+lamivudine+tenofovir Disoproxil Fumarate is not recommended for children weighing below 35kgs. Consult your doctor if you have any concerns.
Habit Forming
Diet & Lifestyle Advise
- Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
- Never share personal items with body fluids or blood on them, such as razor blades or toothbrushes.
- Avoid sharing used needles, other injections or drug equipment.
- Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as vegetables and fruits as it helps to boost the immune system. Opt for lean protein and whole grains.
- Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
- Eat bland and low-fat foods, and avoid spicy or oily foods if you experience nausea or vomiting.
- Try to reduce emotional and physical stress by spending time with family or by doing whatever makes you happy.
Special Advise
- Get HIV test done for at least every 3 months.
- Regular kidney and liver function tests, bone mineral density test while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate is advised.
- Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate might affect laboratory test results; inform the person doing the tests that you are taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate.
- Regularly get blood and urine tests done while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate.
Patients Concern
Disease/Condition Glossary
HIV infection: HIV (Human Immunodeficiency Virus) is a virus that attacks the immune system and destroys the white blood cells that help in fighting infection, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. It spreads through body fluids such as semen, vaginal fluid, and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition, and there is no definite cure for it. However, it can be controlled by treating with antiretroviral drugs.
FAQs
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate contains Dolutegravir, Lamivudine, and Tenofovir disoproxil fumarate. Dolutegravir increases the immune cells that help fight infections in the body and decreases the amount of HIV in the blood. Lamivudine and Tenofovir disoproxil fumarate work by interfering with the working of nucleotide and nucleoside reverse transcriptase enzymes which are necessary for the reproduction of the virus. Together, Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate helps in treating HIV infection.
Do not stop taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate without consulting your doctor as it may reduce the effectiveness of anti-HIV therapy. Continue taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate for as long as your doctor has prescribed it to you to treat your condition effectually. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate.
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate might cause lactic acidosis (excess of lactic acid in the blood), a rare but severe side effect. Consult a doctor immediately if you experience stomach pain, vomiting, nausea, drowsiness, and deep rapid breathing, as these could be the signs of lactic acidosis.
Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate may cause bone problems such as bone pain, softening or thinning of bone which might lead to bone fractures. A regular bone density test is advised while taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate.
Antacids, laxatives, or other medicines containing magnesium, aluminium or buffered medicines (medicines used to neutralise stomach acids) should be taken 2 hours before and 6 hours after taking Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate. Consult your doctor if you have any concerns.
You can take iron or calcium supplements with Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate if you have taken Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate with food. If you haven’t taken Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate with food, take Dolutegravir+lamivudine+tenofovir Disoproxil Fumarate 2 hours before or 6 hours after taking iron or calcium supplements. Consult your doctor if you have any concerns.
